Personal profile

Research interests

Katharine’s overall goal is to develop improved mechanical circulatory support devices for patients with severe heart failure. To do this Katharine works in three main areas:

  1. Design optimisation of ventricular assist devices (VADs) and other types of artificial heart. Katharine mainly uses CFD and numerical models of blood damage, but also works on validation, using optical methods, and improvement of CFD methods.
  2. Investigation of the interaction between mechanical circulatory support and the native cardiovascular system. This involves studying the effects of altered blood flow on blood, for example the trauma induced on the blood cells and proteins, as well as on the blood vessels.
  3. Development of new techniques for studying the above, for example Ultrasound Imaging Velocimetry, a novel method for using ultrasound to measure blood velocity.

Katharine is also interested in other biofluid mechanics, and related bioengineering, problems and has recently worked on mock artery flow rigs, altering the flow in vascular bioreactors and measuring flow changes after nephrectomy.

Katharine’s research has led to consultancy work for companies including Calon Cardio-Technology Ltd and CorWave SAS, and has been used by the US Food and Drug Administration.

Willing to supervise PhD

All areas of blood flow, mechanical circulatory support, and cardiovascular biomechanics

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Projects 2015 2016

Research Output 2004 2018

Experimental Measurement and Numerical Modelling of Dye Washout for Investigation of Blood Residence Time in Ventricular Assist Devices

Molteni, A., Masri, Z., Low, K., Yousef, H., Sienz, J. & Fraser, K. Apr 2018 In : The International Journal of Artificial Organs. 41, 4, p. 201-212

Research output: Contribution to journalArticle

Open Access
Heart-Assist Devices
Coloring Agents
Secondary flow

Blood residence times in Ventricular Assist Devices

Masri, Z., Molteni, A., Yousef, H., Low, K., Porter, H. & Fraser, K. 24 Jun 2017 1 p.

Research output: Contribution to conferencePoster

residence time
shear stress

Experimental and Numerical Analysis of Dye Washout in Ventricular Assist Devices

Molteni, A., Yousef, H., Low, K., Porter, H. & Fraser, K. 1 Apr 2017 In : Journal of Heart and Lung Transplantation. 36, 4, p. S324 997

Research output: Contribution to journalMeeting abstract

Heart-Assist Devices
Coloring Agents

Leukocyte deformation in cardiac assist devices

Fraser, K. & Pieper, I. L. 10 Apr 2017 p. 442 445 p.

Research output: Contribution to conferencePaper

Heart-Assist Devices
Equipment and Supplies
Open Access
Heart-Assist Devices
Shear stress
Strain rate