The chemistry of some dihydropyridines and the synthesis of ellipticine derivatives.

Abstract

A brief summary of the anti-cancer activity of the ellipticines is made together with an indication of the geographical distribution of plants containing ellipticine and related alkaloids. A comprehensive review of the reported synthetic routes to ellipticine and its derivatives is included. During the course of investigations of one route to the tetracyclic system several new dihydropyridines have been isolated and identified. Modification of this route has led to the preparation of several, previously unreported, ellipticine derivatives while the examination of a new synthetic route has led to the preparation of 5-ethylellipticine. Attempts have been made to adapt this procedure to the preparation of other derivatives.

Date of Award	1979
Original language	English
Awarding Institution	University of Bath