Sulphydryl-dependent reactions of D-penicillamine: Pharmacokinetics and effects on monocyte function in rheumatoid arthritis.

  • David Huw Llewellyn

Student thesis: Doctoral ThesisPhD


The project consisted of two major sections:- (i) A high performance liquid chromatography assay to determine total D-penicillamine in human plasma was developed and modified. The final system comprised two columns together with a switching valve, coupled with an electrochemical detector fitted with a sulphydryl-specific amalgamated gold electrode. The resultant chromatography was rapid, exhibited high sensitivity (
Date of Award1985
Original languageEnglish
Awarding Institution
  • University of Bath

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