AbstractOver the last 40 years, little progress has been made in improving the treatment outcomes of pancreatic ductal adenocarcinoma (PDAC). The desmoplastic and hypo-vascular microenvironment of this cancer limits access to therapeutic strategies. Stellate cells, comprising the majority of stroma and secreting large amount of extracellular matrix (ECM), have been suggested to provide a supportive environment for pancreatic cancer whilst playing a suppressive role in cancer growth. In order to identify strategies capable of modulating pancreatic cancer stroma without promoting cancer growth, it is imperative to establish an in vitro human cancer model resembling the human cancer microenvironment.
|Date of Award||13 Feb 2019|
|Supervisor||Paul De Bank (Supervisor), Amanda Mackenzie (Supervisor), Stephen Ward (Supervisor) & Randy Mrsny (Supervisor)|
Molecular mechanisms of YAP signalling in the context of cancer
Xie, B. (Author). 13 Feb 2019
Student thesis: Doctoral Thesis › PhD