Molecular mechanisms of YAP signalling in the context of cancer

  • Bailu Xie

Student thesis: Doctoral ThesisPhD


Over the last 40 years, little progress has been made in improving the treatment outcomes of pancreatic ductal adenocarcinoma (PDAC). The desmoplastic and hypo-vascular microenvironment of this cancer limits access to therapeutic strategies. Stellate cells, comprising the majority of stroma and secreting large amount of extracellular matrix (ECM), have been suggested to provide a supportive environment for pancreatic cancer whilst playing a suppressive role in cancer growth. In order to identify strategies capable of modulating pancreatic cancer stroma without promoting cancer growth, it is imperative to establish an in vitro human cancer model resembling the human cancer microenvironment.
Date of Award13 Feb 2019
Original languageEnglish
Awarding Institution
  • University of Bath
SupervisorPaul De Bank (Supervisor), Amanda Mackenzie (Supervisor), Stephen Ward (Supervisor) & Randy Mrsny (Supervisor)

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