Mammalian metabolic and transport studies with 3-deoxy-3-fluoro-d-glucose.

Abstract

The Biochemistry of Carbon-Fluorine compounds is reviewed. An attempt to premiere titivated 3-Beoxy-3-Pluoro-D-Glucose (3FG) was unsuccessful, because of decomposition of the sugar during the tritiunechange. 3FG is shown to have no effect on gluconeogenesis in rat Kidney Sorted slices. 3FG administered to rats in non-toxic and ramidly exepcted in 24 hours. An to 11% of the total fluoride excreted, spears as free fluoride ion. Bis hydrolysis was not accounted for by acid or base catalysis, on microbial depredation in the urine of the animal. Constituted glycolytic enzyme system which consumes 3FG, does not release fluoride ion. 3FG is not totally excreted by the animals, a small but significant amount brain retained by the brain and testis. Part II The parameters of hexose transport across the human erythrocyte membrane are determined for several sugars, using an optical method. The series of helf-peturation constants is as follows: 3FS=3-9-ethyl-D-Glucose

Date of Award	1973
Original language	English
Awarding Institution	University of Bath