Light-activated Caged Iron Chelators (CICs) for Skin Photoprotection

  • Annabel Hampshire

Student thesis: Doctoral ThesisPhD

Abstract

UV radiation from the sun to which the skin is exposed is largely UVA. UVA is oxidative in nature and may generate redox-active labile iron within skin cells, inducing severe damage through the production of reactive oxygen species (ROS), and leading to skin photoaging and cancer. Light-activated caged iron chelators (CICs) are compounds that become active when exposed to environmentally relevant doses of UVA, releasing a potent iron-trapping agent or chelator, and providing UVA dose-dependent protection from harmful labile iron.
Date of Award19 Nov 2019
Original languageEnglish
Awarding Institution
  • University of Bath
SupervisorIan Eggleston (Supervisor) & Charareh Pourzand (Supervisor)

Keywords

  • UVA
  • Labile iron
  • Iron chelator
  • Photoprotection

Cite this

Light-activated Caged Iron Chelators (CICs) for Skin Photoprotection
Hampshire, A. (Author). 19 Nov 2019

Student thesis: Doctoral ThesisPhD