Light-activated Caged Iron Chelators (CICs) for Skin Photoprotection

Abstract

UV radiation from the sun to which the skin is exposed is largely UVA. UVA is oxidative in nature and may generate redox-active labile iron within skin cells, inducing severe damage through the production of reactive oxygen species (ROS), and leading to skin photoaging and cancer. Light-activated caged iron chelators (CICs) are compounds that become active when exposed to environmentally relevant doses of UVA, releasing a potent iron-trapping agent or chelator, and providing UVA dose-dependent protection from harmful labile iron.

Date of Award	19 Nov 2019
Original language	English
Awarding Institution	University of Bath
Supervisor	Ian Eggleston (Supervisor) & Charareh Pourzand (Supervisor)