Neurodegenerative diseases like Alzheimer’s Disease and Parkinson’s Disease are one of the biggest issues in healthcare that society is facing worldwide. Aging is a major risk factor for many neurodegenerative diseases and is thought to play a large role in their pathology. It is thought that the brain’s resident immune cells microglia can change with age to obtain a detrimental phenotype that disrupts tissue homeostasis and promotes conditions for neurodegenerative disease to develop. Therefore, understanding and implementing microglial aging into the study of neurodegeneration could be important to further advances in the area.
| Date of Award | 13 Feb 2019 |
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| Original language | English |
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| Awarding Institution | |
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| Supervisor | Robert Williams (Supervisor) & David Brown (Supervisor) |
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Inducing Age Related Changes in Microglia as a Model for Neurodegenerative Disease
Angelova, D. (Author). 13 Feb 2019
Student thesis: Doctoral Thesis › PhD