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Showing results for cancer as a concept
2008
8 Citations (Scopus)

A comparison of two orally bioavailable anti-cancer agents, IRC-110160 and STX140

Foster, P. A., Stengel, C., Ali, T., Leese, M. P., Potter, B. V. L., Reed, M. J., Purohit, A. & Newman, S. P., 2008, In : Anticancer Research. 28, 3A, p. 1483-1491

Research output: Contribution to journalArticle

Neoplasms
Carbonic Anhydrase II
P-Glycoprotein
Hormones
2-methoxyoestra-1,3,5(10),16-tetraene-3-carboxamide
30 Citations (Scopus)

A new therapeutic strategy against hormone-dependent breast cancer: the preclinical development of a dual aromatase and sulfatase inhibitor

Foster, P. A., Chander, S. K., Newman, S. P., Woo, L. W. L., Sutcliffe, O. B., Bubert, C., Zhou, D. J., Chen, S. A., Potter, B. V. L., Reed, M. J. & Purohit, A., 15 Oct 2008, In : Clinical Cancer Research. 14, 20, p. 6469-6477

Research output: Contribution to journalArticle

Steryl-Sulfatase
Sulfatases
Aromatase Inhibitors
Aromatase
Hormones
21 Citations (Scopus)

Cardiorespiratory fitness as a predictor of cancer mortality among men with pre-diabetes and diabetes

Thompson, A. M., Church, T. S., Janssen, I., Katzmarzyk, P. T., Earnest, C. P. & Blair, S. N., 2008, In : Diabetes Care. 31, 4, p. 764-769 6 p.

Research output: Contribution to journalArticle

Mortality
Neoplasms
Type 2 Diabetes Mellitus
Longitudinal Studies
Research Design
62 Citations (Scopus)

Chiral aromatase and dual aromatase−steroid sulfatase inhibitors from the letrozole template: synthesis, absolute configuration, and in vitro activity

Wood, P. M., Woo, L. W. L., Labrosse, J-R., Trusselle, M. N., Abbate, S., Longhi, G., Castiglioni, E., Lebon, F., Purohit, A., Reed, M. J. & Potter, B. V. L., 2008, In : Journal of Medicinal Chemistry. 51, 14, p. 4226-4238

Research output: Contribution to journalArticle

letrozole
Steryl-Sulfatase
Aromatase Inhibitors
Aromatase
Inhibitory Concentration 50
8 Citations (Scopus)

Cisplatin and siRNA interference with structure and function of Wnt-5a mRNA: design and in vitro evaluation of targeting AU-rich elements in the 3' UTR

Hägerlöf, M., Papsai, P., Hedman, H. K., Jungwirth, U., Jenei, V. & Elmroth, S. K. C., Mar 2008, In : Journal of Biological Inorganic Chemistry. 13, 3, p. 385-99 15 p.

Research output: Contribution to journalArticle

AU Rich Elements
3' Untranslated Regions
RNA Interference
Small Interfering RNA
Cisplatin
43 Citations (Scopus)

Constitutively active Akt1 expression in mouse pancreas requires S6 kinase 1 for insulinoma formation

Alliouachene, S., Tuttle, R. L., Boumard, S., Lapointe, T., Berissi, S., Germain, S., Jaubert, F., Tosh, D., Birnbaum, M. J. & Pende, M., Nov 2008, In : Journal of Clinical Investigation. 118, 11, p. 3629-3638 10 p.

Research output: Contribution to journalArticle

Ribosomal Protein S6 Kinases
Insulinoma
Pancreas
Insulin
Sirolimus
81 Citations (Scopus)

Distinct methylation changes at the IGF2-H19 locus in congenital growth disorders and cancer

Murrell, A., Ito, Y., Verde, G., Huddleston, J., Woodfine, K., Silengo, M. C., Spreafico, F., Perotti, D., De Crescenzo, A., Sparago, A., Cerrato, F. & Riccio, A., 2008, In : PLoS ONE. 3, 3, e1849.

Research output: Contribution to journalArticle

growth disorders
Growth Disorders
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Methylation
methylation
24 Citations (Scopus)

Effects of C-17 heterocyclic substituents on the anticancer activity of 2-ethylestra-1,3,5(10)-triene-3-O-sulfamates: synthesis, in vitro evaluation and computational modelling

Jourdan, F., Bubert, C., Leese, M. P., Smith, A., Ferrandis, E., Regis-Lydi, S., Newman, S. P., Purohit, A., Reed, M. J. & Potter, B. V. L., 2008, In : Organic and Biomolecular Chemistry. 6, 22, p. 4108-4119

Research output: Contribution to journalArticle

trienes
evaluation
synthesis
Bearings (structural)
Cells
30 Citations (Scopus)

Endothelin-Converting Enzyme-1 Degrades Internalized Somatostatin-14

Roosterman, D., Kempkes, C., Cottrell, G. S., Padilla, B. E., Bunnett, N. W., Turck, C. W. & Steinhoff, M., 1 May 2008, In : Endocrinology. 149, 5, p. 2200-2207 8 p.

Research output: Contribution to journalArticle

Octreotide
Somatostatin
Endopeptidases
Endosomes
Peptides
100 Citations (Scopus)

Epigenetic alteration of Wnt pathway antagonists in progressive glandular neoplasia of the lung

Licchesi, J. D. F., Westra, W. H., Hooker, C. M., Machida, E. O., Baylin, S. B. & Herman, J. G., May 2008, In : Carcinogenesis. 29, 5, p. 895-904 10 p.

Research output: Contribution to journalArticle

Wnt Signaling Pathway
Epigenomics
Hyperplasia
Carcinogenesis
Lung
4 Citations (Scopus)

Evaluation of clinical interventions made by pharmacists in cancer services

Knez, L., Laaksonen, R., Duggan, C. & Nijjar, R., 8 Mar 2008, In : Pharmaceutical Journal. 280, 7492, p. 277-280 4 p.

Research output: Contribution to journalArticle

Pharmacists
Neoplasms
Patient Care
Drug Therapy
Standard of Care

Generation of a genomic tiling array of the human major histocompatibility complex (MHC) and its application for DNA methylation analysis

Tomazou, E. M., Rakyan, V. K., Lefebvre, G., Andrews, R., Ellis, P., Jackson, D. K., Langford, C., Francis, M. D., Bäckdahl, L., Miretti, M., Coggill, P., Ottaviani, D., Sheer, D., Murrell, A. & Beck, S., 2008, In : BMC Medical Genomics. 1, 19.

Research output: Contribution to journalArticle

DNA Methylation
Major Histocompatibility Complex
Epigenomics
Immunity
Genome
26 Citations (Scopus)

Inhibition activity of sulfated polysaccharide of Sepiella maindroni ink on matrix metalloproteinase (MMP)-2

Wang, S. B., Cheng, Y. N., Wang, F. S., Sun, L. R., Liu, C. H., Chen, G. J., Li, Y. H., Ward, S. G. & Qu, X. J., 2008, In : Biomedicine & Pharmacotherapy. 62, 5, p. 297-302 6 p.

Research output: Contribution to journalArticle

Ink
Matrix Metalloproteinase 2
Polysaccharides
Matrix Metalloproteinase 9
Cell Movement
10 Citations (Scopus)

Inhibition of steroid sulphatase activity via the percutaneous route: a new option for breast cancer therapy

Purohit, A., Chander, S. K., Woo, L. W. L., Parsons, M. F. C., Jhalli, R., Potter, B. V. L. & Reed, M. J., 2008, In : Anticancer Research. 28, 3A, p. 1517-1523

Research output: Contribution to journalArticle

Steryl-Sulfatase
Breast Neoplasms
Skin
Therapeutics
Liver
14 Citations (Scopus)

Kinetochore structure and spindle assembly checkpoint signaling in the budding yeast, Saccharomyces Cerevisiae

Clarke, D. J. & Bachant, J., 1 May 2008, In : Frontiers in Bioscience. 13, 17, p. 6787-6819 33 p.

Research output: Contribution to journalArticle

M Phase Cell Cycle Checkpoints
Kinetochores
Saccharomycetales
Yeast
Saccharomyces cerevisiae
150 Citations (Scopus)
100 Downloads (Pure)

PcG proteins, DNA methylation, and gene repression by chromatin looping

Tiwari, V. K., McGarvey, K. M., Licchesi, J. D. F., Ohm, J. E., Herman, J. G., Schübeler, D. & Baylin, S. B., 2 Dec 2008, In : PLoS Biology. 6, 12, p. 2911-2927 17 p.

Research output: Contribution to journalArticle

Open Access
File
Polycomb-Group Proteins
DNA methylation
DNA Methylation
Transcription
Chromatin
38 Citations (Scopus)

Plasma membrane expression of GnRH receptors: regulation by antagonists in breast, prostate, and gonadotrope cell lines.

Finch, A. R., Sedgley, K. R., Caunt, C. J. & McArdle, C. A., 2008, In : The Journal of Endocrinology. 196, 2, p. 353-367 15 p.

Research output: Contribution to journalArticle

LHRH Receptors
Prostate
Breast
Cell Membrane
Cell Line
74 Citations (Scopus)

Promoter hypermethylation of hallmark cancer genes in atypical adenomatous hyperplasia of the lung

Licchesi, J. D. F., Westra, W. H., Hooker, C. M. & Herman, J. G., 1 May 2008, In : Clinical Cancer Research. 14, 9, p. 2570-2578 9 p.

Research output: Contribution to journalArticle

Neoplasm Genes
Epigenomics
Hyperplasia
Carcinogenesis
Lung
32 Citations (Scopus)

Promoting early presentation of breast cancer: development of a psycho-educational intervention

Burgess, C. C., Bish, A. M., Hunter, H. S., Salkovskis, P. M., Michell, M., Whelehan, P. & Ramirez, A. J., 2008, In : Chronic Illness. 4, 1, p. 13-27 15 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Pamphlets
National Health Programs
Breast
Randomized Controlled Trials
83 Citations (Scopus)

Psychologic predictors of cancer information avoidance among older adults: the role of cancer fear and fatalism

Miles, A., Voorwinden, S., Chapman, S. & Wardle, J., Aug 2008, In : Cancer Epidemiology, Biomarkers and Prevention. 17, 8, p. 1872-1879 8 p.

Research output: Contribution to journalArticle

Fear
Neoplasms
Emotions
Research
47 Citations (Scopus)
78 Downloads (Pure)

RASSF7 is a member of a new family of RAS association domain- containing proteins and is required for completing mitosis

Sherwood, V., Manbodh, R., Sheppard, C. & Chalmers, A. D., 1 Apr 2008, In : Molecular Biology of the Cell. 19, 4, p. 1772-1782 11 p.

Research output: Contribution to journalArticle

Open Access
Mitosis
Neural Tube
Centrosome
Proteins
Spindle Apparatus
173 Citations (Scopus)

Resistance against novel anticancer metal compounds: differences and similarities

Heffeter, P., Jungwirth, U., Jakupec, M., Hartinger, C., Galanski, M., Elbling, L., Micksche, M., Keppler, B. & Berger, W., 9 Apr 2008, In : Drug Resistance Updates. 11, 1-2, p. 1-16 16 p.

Research output: Contribution to journalReview article

Metals
oxaliplatin
Drug Resistance
Platinum Compounds
Lanthanum
32 Citations (Scopus)

Role of Ena/VASP Proteins in Homeostasis and Disease

Pula, G. & Krause, M., 2008, In : Handbook of experimental pharmacology. 186, 1, p. 39-65 27 p.

Research output: Contribution to journalArticle

Homeostasis
Actin Cytoskeleton
Actins
Proteins
Blood Preservation
152 Citations (Scopus)

Role of miRNA-146a in the regulation of the innate immune response and cancer

Williams, A. E., Perry, M. M., Moschos, S. A., Larner-Svensson, H. M. & Lindsay, M. A., 2008, In : Biochemical Society Transactions. 36, 6, p. 1211-1215 5 p.

Research output: Contribution to journalArticle

MicroRNAs
Innate Immunity
Inflammation
Small Untranslated RNA
Neoplasms
102 Citations (Scopus)

Somatically acquired hypomethylation of IGF2 in breast and colorectal cancer

Ito, Y., Koessler, T., Ibrahim, A. E. K., Rai, S., Vowler, S. L., Abu-Amero, S., Silva, A-L., Maia, A-T., Huddleston, J. E., Uribe-Lewis, S., Woodfine, K., Jagodic, M., Nativio, R., Dunning, A., Moore, G., Klenova, E., Bingham, S., Pharoah, P. D. P., Brenton, J. D., Beck, S. & 2 others, Sandhu, M. S. & Murrell, A., 1 Sep 2008, In : Human Molecular Genetics. 17, 17, p. 2633-2643 11 p.

Research output: Contribution to journalArticle

Somatomedins
Colorectal Neoplasms
Breast Neoplasms
Neoplasms
Methylation