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Showing results for cancer as a concept
2010
49 Citations (Scopus)

The RASSF8 candidate tumor suppressor inhibits cell growth and regulates the Wnt and NF-κB signaling pathways

Lock, F. E., Underhill-Day, N., Dunwell, T., Matallanas, D., Cooper, W., Hesson, L., Recino, A., Ward, A., Pavlova, T., Zabarovsky, E., Grant, M. M., Maher, E. R., Chalmers, A. D., Kolch, W. & Latif, F., 2010, In : Oncogene. 29, 30, p. 4307-4316 10 p.

Research output: Contribution to journalArticle

Wnt Proteins
beta Catenin
Adherens Junctions
Growth
Cadherins
27 Citations (Scopus)

The retinoblastoma protein modulates Tbx2 functional specificity

Vance, K. W., Shaw, H. M., Rodriguez, M., Ott, S. & Goding, C. R., 1 Aug 2010, In : Molecular Biology of the Cell. 21, 15, p. 2770-9 10 p.

Research output: Contribution to journalArticle

Retinoblastoma Protein
Transcription Factors
Tissue Array Analysis
Cell Cycle Checkpoints
Genes
17 Citations (Scopus)

The role of Cdx2 in Barrett's metaplasia

Colleypriest, B. J., Farrant, J. M., Slack, J. M. W. & Tosh, D., Apr 2010, In : Biochemical Society Transactions. 38, 2, p. 364-369 6 p.

Research output: Contribution to journalArticle

Barrett Esophagus
Homeobox Genes
Metaplasia
Transcription Factors
Tissue
2009
16 Citations (Scopus)

BCRP expression does not result in resistance to STX140 in vivo, despite the increased expression of BCRP in A2780 cells in vitro after long-term STX140 exposure

Day, J. M., Foster, P. A., Tutill, H. J., Newman, S. P., Ho, Y. T., Leese, M. P., Potter, B. V. L., Reed, M. J. & Purohit, A., 3 Feb 2009, In : British Journal of Cancer. 100, 3, p. 476-486

Research output: Contribution to journalArticle

Breast Neoplasms
Proteins
Cell Line
Mitoxantrone
Heterografts
18 Citations (Scopus)

Blocking phosphoinositide 3-kinase activity in colorectal cancer cells reduces proliferation but does not increase apoptosis alone or in combination with cytotoxic drugs

Martin-Fernandez, C., Bales, J., Hodgkinson, C., Welman, A., Welham, M. J., Dive, C. & Morrow, C. J., 2009, In : Molecular Cancer Research. 7, 6, p. 955-965 11 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Colorectal Neoplasms
Cell Proliferation
Apoptosis
oxaliplatin
24 Citations (Scopus)

Cdx genes, inflammation and the pathogenesis of Barrett's metaplasia

Colleypriest, B. J., Palmer, R. M., Ward, S. G. & Tosh, D., Jul 2009, In : Trends in Molecular Medicine. 15, 7, p. 313-322 10 p.

Research output: Contribution to journalArticle

Barrett Esophagus
Inflammation
Metaplasia
Genes
Adenocarcinoma
16 Citations (Scopus)

Design and synthesis of N 4,N 9-disubstituted spermines for non-viral siRNA delivery – structure-activity relationship studies of siFection efficiency versus toxicity

Soltan, M. K., Ghonaim, H. M., El Sadek, M., Abou Kull, M., El-aziz, L. A. & Blagbrough, I. S., Feb 2009, In : Pharmaceutical Research. 26, 2, p. 286-295 10 p.

Research output: Contribution to journalArticle

Spermine
Structure-Activity Relationship
Small Interfering RNA
Toxicity
Poisons
12 Citations (Scopus)

Development of hormone-dependent prostate cancer models for the evaluation of inhibitors of 17β-hydroxysteroid dehydrogenase Type 3

Day, J. M., Tutill, H. J., Foster, P. A., Bailey, H. V., Heaton, W. B., Sharland, C. M., Vicker, N., Potter, B. V. L., Purohit, A. & Reed, M. J., 2009, In : Molecular and Cellular Endocrinology. 301, 1-2, p. 251-258

Research output: Contribution to journalArticle

Androstenedione
Prostatic Neoplasms
Hormones
Assays
Cells
107 Citations (Scopus)
91 Downloads (Pure)

Frequent long-range epigenetic silencing of Protocadherin gene clusters on chromosome 5q31 in Wilms' Tumor

Dallosso, A. R., Hancock, A. L., Szemes, M., Moorwood, K., Chilukamarri, L., Tsai, H. H., Sarkar, A., Barasch, J., Vuononvirta, R., Jones, C., Pritchard-Jones, K., Royer-Pokora, B., Lee, S. B., Owen, C., Malik, S., Feng, Y., Frank, M., Ward, A., Brown, K. W. & Malik, K., 26 Nov 2009, In : Plos Genetics. 5, 11, 13 p., e1000745.

Research output: Contribution to journalArticle

File
Wilms Tumor
cadherins
Multigene Family
multigene family
Epigenomics
70 Citations (Scopus)

Generation of an epigenetic signature by chronic hypoxia in prostate cells

Watson, J. A., Watson, C. J., McCrohan, A-M., Woodfine, K., Tosetto, M., McDaid, J., Gallagher, E., Betts, D., Baugh, J., O'Sullivan, J., Murrell, A., Watson, R. W. G. & McCann, A., 1 Oct 2009, In : Human Molecular Genetics. 18, 19, p. 3594-3604 11 p.

Research output: Contribution to journalArticle

Epigenomics
Prostate
DNA Methylation
Acetylation
Histones
192 Citations (Scopus)

Myositis-specific autoantibodies: their clinical and pathogenic significance in disease expression

Gunawardena, H., Betteridge, Z. E. & McHugh, N. J., 2009, In : Rheumatology. 48, 6, p. 607-612 6 p.

Research output: Contribution to journalArticle

Myositis
Autoantibodies
Signal Recognition Particle
Amino Acyl-tRNA Synthetases
Muscle Weakness
34 Citations (Scopus)

Perceived risk of medicine side effects in users of a patient information website: A study of the use of verbal descriptors, percentages and natural frequencies

Knapp, P., Gardner, P. H., Carrigan, N., Raynor, D. K. & Woolf, E., Sep 2009, In : British Journal of Health Psychology. 14, 3, p. 579-594 16 p.

Research output: Contribution to journalArticle

Medicine
Research
Ibuprofen
Paclitaxel
Neoplasms
22 Citations (Scopus)

PI3K isoforms as drug targets in inflammatory diseases: Lessons from pharmacological and genetic strategies

Harris, S. J., Foster, J. G. & Ward, S. G., Nov 2009, In : Current Opinion in Investigational Drugs. 10, 11, p. 1151-1162 12 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinases
Protein Isoforms
Pharmacology
Anti-Inflammatory Agents
Pharmaceutical Preparations
18 Citations (Scopus)

Poly(ADP-Ribose) Polymerase Inhibition Down-Regulates Expression of Metastasis-Related Genes in CT26 Colon Carcinoma Cells

Li, M., Threadgill, M. D., Wang, Y. L., Cai, L. & Lin, X., 2009, In : Pathobiology. 76, 3, p. 108-116 9 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose) Polymerases
Matrix Metalloproteinases
NF-kappa B
Colon
Down-Regulation
6 Citations (Scopus)

Potential use of an estrogen–glucocorticoid receptor chimera as a drug screen for tissue selective estrogenic activity

Maru, B., Tobias, J., Rivers, C., Caunt, C., Norman, M. & McArdle, C., Jan 2009, In : Bone. 44, 1, p. 102-112 11 p.

Research output: Contribution to journalArticle

Glucocorticoid Receptors
Osteoblasts
Estrogen Receptors
Selective Estrogen Receptor Modulators
Green Fluorescent Proteins
7 Citations (Scopus)

Reversal effect of substituted 1,3-dimethyl-1H-quinoxalin-2-ones on multidrug resistance in adriamycin-resistant K562/A02 cells

Sun, L. R., Li, X., Cheng, Y. N., Yuan, H. Y., Chen, M. H., Tang, W., Ward, S. G. & Qu, X. J., 2009, In : Biomedicine & Pharmacotherapy. 63, 3, p. 202-208 7 p.

Research output: Contribution to journalArticle

Quinoxalines
K562 Cells
Multiple Drug Resistance
varespladib methyl
Doxorubicin
26 Citations (Scopus)

Structures of native human thymidine phosphorylase and in complex with 5-iodouracil

Mitsiki, E., Papageorgiou, A. C., Iyer, S., Thiyagarajan, N., Prior, S. H., Sleep, D., Finnis, C. & Acharya, K. R., 4 Sep 2009, In : Biochemical and Biophysical Research Communications. 386, 4, p. 666-670 5 p.

Research output: Contribution to journalArticle

Thymidine Phosphorylase
Population Groups
Mutagenesis
Nucleosides
Metabolism
6 Citations (Scopus)

STX140 and STX641 cause apoptosis via the intrinsic mitochondrial pathway and down-regulate survivin and XIAP expression in ovarian and prostate cancer cells

Foster, P. A., Ho, Y. T., Newman, S. P., Leese, M. P., Potter, B. V. L., Reed, M. J. & Purohit, A., Oct 2009, In : Anticancer Research. 29, 10, p. 3751-3757 7 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Prostatic Neoplasms
Down-Regulation
Microtubules
Apoptosis
24 Citations (Scopus)

Synthesis and use of isotope-labelled substrates for a mechanistic study on human α-methylacyl-CoA racemase 1A (AMACR; P504S)

Darley, D. J., Butler, D. S., Prideaux, S. J., Thornton, T. W., Wilson, A. D., Woodman, T. J., Threadgill, M. D. & Lloyd, M. D., 7 Feb 2009, In : Organic and Biomolecular Chemistry. 7, 3, p. 543-552 10 p.

Research output: Contribution to journalArticle

Isotopes
enzymes
isotopes
Substrates
Enzymes
22 Citations (Scopus)

The design of novel 17 beta-hydroxysteroid dehydrogenase type 3 inhibitors

Vicker, N., Sharland, C. M., Heaton, W. B., Ramos Gonzalez, A. M., Bailey, H. V., Smith, A., Springall, J. S., Day, J. M., Tutill, H. J., Reed, M. J., Purohit, A. & Potter, B. V. L., 25 Mar 2009, In : Molecular and Cellular Endocrinology. 301, 1-2, p. 259-265

Research output: Contribution to journalArticle

17-Hydroxysteroid Dehydrogenases
Hydroxysteroids
Biosynthesis
Inhibitory Concentration 50
Testosterone
38 Citations (Scopus)

The development of steroid sulfatase iInhibitors for hormone-dependent cancer therapy

Day, J. M., Purohit, A., Tutill, H. J., Foster, P. A., Woo, L. W. L., Potter, B. V. L. & Reed, M. J., 2009, Steroid Enzymes and Cancer. Bradlow, H. L. & Carruba, G. (eds.). Wiley-Blackwell, Vol. 1155. p. 80-87 (Annals of the New York Academy of Sciences).

Research output: Chapter in Book/Report/Conference proceedingChapter

Steryl-Sulfatase
Hormones
Neoplasms
Therapeutics
Steroids
79 Citations (Scopus)
75 Downloads (Pure)

The novel RASSF6 and RASSF10 candidate tumour suppressor genes are frequently epigenetically inactivated in childhood leukaemias

Hesson, L. B., Dunwell, T. L., Cooper, W. N., Catchpoole, D., Brini, A. T., Chiaramonte, R., Griffiths, M., Chalmers, A. D., Maher, E. R. & Latif, F., 1 Jul 2009, In : Molecular Cancer. 8, 42

Research output: Contribution to journalArticle

File
Tumor Suppressor Genes
Leukemia
Precursor Cell Lymphoblastic Leukemia-Lymphoma
B-Cell Leukemia
Methylation
12 Citations (Scopus)

Very long chain N4,N9-diacyl spermines: non-viral lipopolyamine V vectors for efficient plasmid DNA and siRNA delivery

Ghonaim, H. M., Li, S. & Blagbrough, I. S., 1 Jan 2009, In : Pharmaceutical Research. 26, 1, p. 19-31 13 p.

Research output: Contribution to journalArticle

Spermine
Small Interfering RNA
Plasmids
Nanoparticles
DNA
2008
29 Citations (Scopus)

2-MeOE2bisMATE and 2-EtE2bisMATE induce cell cycle arrest and apoptosis in breast cancer xenografts as shown by a novel ex vivo technique

Foster, P. A., Ho, Y. T., Newman, S. P., Kasprzyk, P. G., Leese, M. P., Potter, B. V. L., Reed, M. J. & Purohit, A., 2008, In : Breast Cancer Research and Treatment. 111, 2, p. 251-260

Research output: Contribution to journalArticle

Cell Cycle Checkpoints
Heterografts
Apoptosis
Breast Neoplasms
Neoplasms
29 Citations (Scopus)

2-Methoxyoestradiol-3,17-O,O-bis-sulphamate and 2-deoxy-D-glucose in combination: a potential treatment for breast and prostate cancer

Tagg, S. L. C., Foster, P. A., Leese, M. P., Potter, B. V. L., Reed, M. J., Purohit, A. & Newman, S. P., 2008, In : British Journal of Cancer. 99, 11, p. 1842-1848

Research output: Contribution to journalArticle

Deoxyglucose
Prostatic Neoplasms
Breast Neoplasms
Tumor Burden
Heterografts