Zirconium Amine Tris(phenolate)

A More Effective Initiator for Biomedical Lactide

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Abstract

Here a zirconium amine tris(phenolate) is used as the initiator for the production of polylactide for biomedical applications, as a replacement for a tin initiator (usually tin octanoate). The ring opening polymerization (ROP) was carried out in the melt at 130 ºC. The zirconium-catalyzed PLA (PLA-Zr) required 30 min, resulting in a polydispersity index (PDI) of 1.17, compared to 1h and PDI=1.77 for tin-catalyzed PLA (PLA-Sn). PLA-Zr and PLA-Sn supported osteosarcoma cell (MG63) culture to the same extent (cell number, morphology, extracellular matrix production and osteogenic function) until day 14 when the PLA-Zr showed increased cell number, overall extracellular matrix production and osteogenic function. To conclude, the reduction in reaction time, controllable microstructure and biologically benign nature of the zirconium amine tris(phenolate) initiator shows that it is a more effective initiator for ROP of polylactide for biomedical applications
Original languageEnglish
Pages (from-to)69-74
Journal Materials Science and Engineering C - Biomimetics Materials Sensors and Systems
Volume80
Early online date29 Mar 2017
DOIs
Publication statusPublished - 1 Nov 2017

Fingerprint

Tin
initiators
Zirconium
Amines
amines
Ring opening polymerization
Polydispersity
tin
polymerization
cells
Cell culture
rings
matrices
reaction time
Microstructure
microstructure
dilactide
poly(lactide)

Cite this

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title = "Zirconium Amine Tris(phenolate): A More Effective Initiator for Biomedical Lactide",
abstract = "Here a zirconium amine tris(phenolate) is used as the initiator for the production of polylactide for biomedical applications, as a replacement for a tin initiator (usually tin octanoate). The ring opening polymerization (ROP) was carried out in the melt at 130 ºC. The zirconium-catalyzed PLA (PLA-Zr) required 30 min, resulting in a polydispersity index (PDI) of 1.17, compared to 1h and PDI=1.77 for tin-catalyzed PLA (PLA-Sn). PLA-Zr and PLA-Sn supported osteosarcoma cell (MG63) culture to the same extent (cell number, morphology, extracellular matrix production and osteogenic function) until day 14 when the PLA-Zr showed increased cell number, overall extracellular matrix production and osteogenic function. To conclude, the reduction in reaction time, controllable microstructure and biologically benign nature of the zirconium amine tris(phenolate) initiator shows that it is a more effective initiator for ROP of polylactide for biomedical applications",
author = "Jones, {Matthew D} and Xujun Wu and Julian Chaudhuri and Davidson, {Matthew G} and Ellis, {Marianne J}",
year = "2017",
month = "11",
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doi = "10.1016/j.msec.2017.03.242",
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volume = "80",
pages = "69--74",
journal = "Materials Science & Engineering C",
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TY - JOUR

T1 - Zirconium Amine Tris(phenolate)

T2 - A More Effective Initiator for Biomedical Lactide

AU - Jones, Matthew D

AU - Wu, Xujun

AU - Chaudhuri, Julian

AU - Davidson, Matthew G

AU - Ellis, Marianne J

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Here a zirconium amine tris(phenolate) is used as the initiator for the production of polylactide for biomedical applications, as a replacement for a tin initiator (usually tin octanoate). The ring opening polymerization (ROP) was carried out in the melt at 130 ºC. The zirconium-catalyzed PLA (PLA-Zr) required 30 min, resulting in a polydispersity index (PDI) of 1.17, compared to 1h and PDI=1.77 for tin-catalyzed PLA (PLA-Sn). PLA-Zr and PLA-Sn supported osteosarcoma cell (MG63) culture to the same extent (cell number, morphology, extracellular matrix production and osteogenic function) until day 14 when the PLA-Zr showed increased cell number, overall extracellular matrix production and osteogenic function. To conclude, the reduction in reaction time, controllable microstructure and biologically benign nature of the zirconium amine tris(phenolate) initiator shows that it is a more effective initiator for ROP of polylactide for biomedical applications

AB - Here a zirconium amine tris(phenolate) is used as the initiator for the production of polylactide for biomedical applications, as a replacement for a tin initiator (usually tin octanoate). The ring opening polymerization (ROP) was carried out in the melt at 130 ºC. The zirconium-catalyzed PLA (PLA-Zr) required 30 min, resulting in a polydispersity index (PDI) of 1.17, compared to 1h and PDI=1.77 for tin-catalyzed PLA (PLA-Sn). PLA-Zr and PLA-Sn supported osteosarcoma cell (MG63) culture to the same extent (cell number, morphology, extracellular matrix production and osteogenic function) until day 14 when the PLA-Zr showed increased cell number, overall extracellular matrix production and osteogenic function. To conclude, the reduction in reaction time, controllable microstructure and biologically benign nature of the zirconium amine tris(phenolate) initiator shows that it is a more effective initiator for ROP of polylactide for biomedical applications

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DO - 10.1016/j.msec.2017.03.242

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