Zebrafish pigmentation mutations and the processes of neural crest development

R N Kelsh, M Brand, Y J Jiang, C P Heisenberg, S Lin, P Haffter, J Odenthal, M C Mullins, F J M vanEeden, Makoto Furutani-Seiki, M Granato, M Hammerschmidt, D A Kane, R M Warga, D Beuchle, L Vogelsang, C NussleinVolhard

Research output: Contribution to journalArticle

315 Citations (Scopus)

Abstract

Neural crest development involves cell-fate specification, proliferation, patterned cell migration, survival and differentiation, Zebrafish neural crest derivatives include three distinct chromatophores, which are well-suited to genetic analysis of their development, As part of a large-scale mutagenesis screen for embryonic/early larval mutations, we have isolated 285 mutations affecting all aspects of zebrafish larval pigmentation, By complementation analysis, we define 94 genes, We show here that comparison of their phenotypes permits classification of these mutations according to the types of defects they cause, and these suggest which process of neural crest development is probably affected, Mutations in eight genes affect the number of chromatophores: these include strong candidates for genes necessary for the processes of pigment cell specification and proliferation, Mutations in five genes remove part of the wild-type pigment pattern, and suggest a role in larval pigment pattern formation, Mutations in five genes show ectopic chromatophores in distinct sites, and may have implications for chromatophore patterning and proliferation, 76 genes affect pigment or morphology of one or more chromatophore types: these mutations include strong candidates for genes important in various aspects of chromatophore differentiation and survival, In combination with the embryological advantages of zebrafish, these mutations should permit cellular and molecular dissection of many aspects of neural crest development.
Original languageEnglish
Pages (from-to)369-389
Number of pages21
JournalDevelopment
Volume123
Publication statusPublished - 1996

Fingerprint

Neural Crest
Pigmentation
Zebrafish
Chromatophores
Mutation
Genes
Mutagenesis
Cell Movement
Dissection
Cell Differentiation
Cell Survival
Cell Proliferation
Phenotype

Keywords

  • iridophore
  • proliferation
  • differentiation
  • specification
  • melanophore
  • survival
  • xanthophore

Cite this

Kelsh, R. N., Brand, M., Jiang, Y. J., Heisenberg, C. P., Lin, S., Haffter, P., ... NussleinVolhard, C. (1996). Zebrafish pigmentation mutations and the processes of neural crest development. Development, 123, 369-389.

Zebrafish pigmentation mutations and the processes of neural crest development. / Kelsh, R N; Brand, M; Jiang, Y J; Heisenberg, C P; Lin, S; Haffter, P; Odenthal, J; Mullins, M C; vanEeden, F J M; Furutani-Seiki, Makoto; Granato, M; Hammerschmidt, M; Kane, D A; Warga, R M; Beuchle, D; Vogelsang, L; NussleinVolhard, C.

In: Development, Vol. 123, 1996, p. 369-389.

Research output: Contribution to journalArticle

Kelsh, RN, Brand, M, Jiang, YJ, Heisenberg, CP, Lin, S, Haffter, P, Odenthal, J, Mullins, MC, vanEeden, FJM, Furutani-Seiki, M, Granato, M, Hammerschmidt, M, Kane, DA, Warga, RM, Beuchle, D, Vogelsang, L & NussleinVolhard, C 1996, 'Zebrafish pigmentation mutations and the processes of neural crest development', Development, vol. 123, pp. 369-389.
Kelsh RN, Brand M, Jiang YJ, Heisenberg CP, Lin S, Haffter P et al. Zebrafish pigmentation mutations and the processes of neural crest development. Development. 1996;123:369-389.
Kelsh, R N ; Brand, M ; Jiang, Y J ; Heisenberg, C P ; Lin, S ; Haffter, P ; Odenthal, J ; Mullins, M C ; vanEeden, F J M ; Furutani-Seiki, Makoto ; Granato, M ; Hammerschmidt, M ; Kane, D A ; Warga, R M ; Beuchle, D ; Vogelsang, L ; NussleinVolhard, C. / Zebrafish pigmentation mutations and the processes of neural crest development. In: Development. 1996 ; Vol. 123. pp. 369-389.
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AU - Odenthal, J

AU - Mullins, M C

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AB - Neural crest development involves cell-fate specification, proliferation, patterned cell migration, survival and differentiation, Zebrafish neural crest derivatives include three distinct chromatophores, which are well-suited to genetic analysis of their development, As part of a large-scale mutagenesis screen for embryonic/early larval mutations, we have isolated 285 mutations affecting all aspects of zebrafish larval pigmentation, By complementation analysis, we define 94 genes, We show here that comparison of their phenotypes permits classification of these mutations according to the types of defects they cause, and these suggest which process of neural crest development is probably affected, Mutations in eight genes affect the number of chromatophores: these include strong candidates for genes necessary for the processes of pigment cell specification and proliferation, Mutations in five genes remove part of the wild-type pigment pattern, and suggest a role in larval pigment pattern formation, Mutations in five genes show ectopic chromatophores in distinct sites, and may have implications for chromatophore patterning and proliferation, 76 genes affect pigment or morphology of one or more chromatophore types: these mutations include strong candidates for genes important in various aspects of chromatophore differentiation and survival, In combination with the embryological advantages of zebrafish, these mutations should permit cellular and molecular dissection of many aspects of neural crest development.

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KW - proliferation

KW - differentiation

KW - specification

KW - melanophore

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