Zebrafish adult pigment stem cells are multipotent and form pigment cells by a progressive fate restriction process

Clonal analysis identifies shared origin of all pigment cell types

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Abstract

Skin pigment pattern formation is a paradigmatic example of pattern formation. In zebrafish, the adult body stripes are generated by coordinated rearrangement of three distinct pigment cell-types, black melanocytes, shiny iridophores and yellow xanthophores. A stem cell origin of melanocytes and iridophores has been proposed although the potency of those stem cells has remained unclear. Xanthophores, however, seemed to originate predominantly from proliferation of embryonic xanthophores. Now, data from Singh et al. shows that all three cell-types derive from shared stem cells, and that these cells generate peripheral neural cell-types too. Furthermore, clonal compositions are best explained by a progressive fate restriction model generating the individual cell-types. The numbers of adult pigment stem cells associated with the dorsal root ganglia remain low, but progenitor numbers increase significantly during larval development up to metamorphosis, likely via production of partially restricted progenitors on the spinal nerves.

Original languageEnglish
Article number1600234
JournalBioessays
Volume39
Issue number3
Early online date23 Dec 2016
DOIs
Publication statusPublished - 1 Mar 2017

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Adult Stem Cells
Zebrafish
Stem cells
Pigments
Stem Cells
Melanocytes
Spinal Nerves
Spinal Ganglia
Skin
Chemical analysis

Keywords

  • Zebrafish
  • multipotent stem cell
  • chromoblast
  • iridophores
  • xanthophores
  • melanophores

Cite this

@article{7a51bc388abb4d2d97c9a15cc7b4c4b5,
title = "Zebrafish adult pigment stem cells are multipotent and form pigment cells by a progressive fate restriction process: Clonal analysis identifies shared origin of all pigment cell types",
abstract = "Skin pigment pattern formation is a paradigmatic example of pattern formation. In zebrafish, the adult body stripes are generated by coordinated rearrangement of three distinct pigment cell-types, black melanocytes, shiny iridophores and yellow xanthophores. A stem cell origin of melanocytes and iridophores has been proposed although the potency of those stem cells has remained unclear. Xanthophores, however, seemed to originate predominantly from proliferation of embryonic xanthophores. Now, data from Singh et al. shows that all three cell-types derive from shared stem cells, and that these cells generate peripheral neural cell-types too. Furthermore, clonal compositions are best explained by a progressive fate restriction model generating the individual cell-types. The numbers of adult pigment stem cells associated with the dorsal root ganglia remain low, but progenitor numbers increase significantly during larval development up to metamorphosis, likely via production of partially restricted progenitors on the spinal nerves.",
keywords = "Zebrafish, multipotent stem cell, chromoblast, iridophores, xanthophores, melanophores",
author = "Kelsh, {Robert N} and {Camargo Sosa}, Karen and Owen, {Jennifer P} and Yates, {Christian A}",
note = "{\circledC} 2016 The Authors BioEssays Published by WILEY Periodicals, Inc.",
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T1 - Zebrafish adult pigment stem cells are multipotent and form pigment cells by a progressive fate restriction process

T2 - Clonal analysis identifies shared origin of all pigment cell types

AU - Kelsh, Robert N

AU - Camargo Sosa, Karen

AU - Owen, Jennifer P

AU - Yates, Christian A

N1 - © 2016 The Authors BioEssays Published by WILEY Periodicals, Inc.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Skin pigment pattern formation is a paradigmatic example of pattern formation. In zebrafish, the adult body stripes are generated by coordinated rearrangement of three distinct pigment cell-types, black melanocytes, shiny iridophores and yellow xanthophores. A stem cell origin of melanocytes and iridophores has been proposed although the potency of those stem cells has remained unclear. Xanthophores, however, seemed to originate predominantly from proliferation of embryonic xanthophores. Now, data from Singh et al. shows that all three cell-types derive from shared stem cells, and that these cells generate peripheral neural cell-types too. Furthermore, clonal compositions are best explained by a progressive fate restriction model generating the individual cell-types. The numbers of adult pigment stem cells associated with the dorsal root ganglia remain low, but progenitor numbers increase significantly during larval development up to metamorphosis, likely via production of partially restricted progenitors on the spinal nerves.

AB - Skin pigment pattern formation is a paradigmatic example of pattern formation. In zebrafish, the adult body stripes are generated by coordinated rearrangement of three distinct pigment cell-types, black melanocytes, shiny iridophores and yellow xanthophores. A stem cell origin of melanocytes and iridophores has been proposed although the potency of those stem cells has remained unclear. Xanthophores, however, seemed to originate predominantly from proliferation of embryonic xanthophores. Now, data from Singh et al. shows that all three cell-types derive from shared stem cells, and that these cells generate peripheral neural cell-types too. Furthermore, clonal compositions are best explained by a progressive fate restriction model generating the individual cell-types. The numbers of adult pigment stem cells associated with the dorsal root ganglia remain low, but progenitor numbers increase significantly during larval development up to metamorphosis, likely via production of partially restricted progenitors on the spinal nerves.

KW - Zebrafish

KW - multipotent stem cell

KW - chromoblast

KW - iridophores

KW - xanthophores

KW - melanophores

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