Why doesn't nicotinic ACh receptor immunoreactivity knock out?

I W Jones, S Wonnacott

Research output: Contribution to journalArticlepeer-review

60 Citations (SciVal)


Immunochemical analyses of protein expression and localization rely on the specificity of primary immunoreagents. A recent report, using transgenic mice, casts doubt on the specificity of three antibodies commonly used to immunolocalize alpha 7 nicotinic ACh receptors. These data highlight the conundrum facing histologists - how 'real' is the labelling they see?
Original languageEnglish
Pages (from-to)343-345
Number of pages3
JournalTrends in Neurosciences
Issue number7
Publication statusPublished - Jul 2005


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