Abstract

We document evidence that the major rate-limiting step in iontophoretic drug delivery of low molecular weight charged solutes can be dermal perfusion at the site of application; for high molecular weight solutes, on the other hand, transport to the site of microcirculation uptake may, in some circumstances, become the slowest step.

Original languageEnglish
Pages (from-to)R1-R5
JournalInternational Journal of Pharmaceutics
Volume101
Issue number3
DOIs
Publication statusPublished - 25 Jan 1994

Bibliographical note

Funding Information:
Supportedi n part by a grantf rom the National Instituteso f Health (HD-27839)t o R.H.G.M.S.R. acknowledgesth e support of National Health & Medical Research Council of Australia and the Queenslanda nd Northern New South Wales Lions and Kidney Medical ResearchF oundation.

Keywords

  • Absorption
  • Iontophoresis
  • Kinetics

ASJC Scopus subject areas

  • Pharmaceutical Science

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