Abstract
We document evidence that the major rate-limiting step in iontophoretic drug delivery of low molecular weight charged solutes can be dermal perfusion at the site of application; for high molecular weight solutes, on the other hand, transport to the site of microcirculation uptake may, in some circumstances, become the slowest step.
| Original language | English |
|---|---|
| Pages (from-to) | R1-R5 |
| Journal | International Journal of Pharmaceutics |
| Volume | 101 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 25 Jan 1994 |
Bibliographical note
Funding Information:Supportedi n part by a grantf rom the National Instituteso f Health (HD-27839)t o R.H.G.M.S.R. acknowledgesth e support of National Health & Medical Research Council of Australia and the Queenslanda nd Northern New South Wales Lions and Kidney Medical ResearchF oundation.
Funding
Supportedi n part by a grantf rom the National Instituteso f Health (HD-27839)t o R.H.G.M.S.R. acknowledgesth e support of National Health & Medical Research Council of Australia and the Queenslanda nd Northern New South Wales Lions and Kidney Medical ResearchF oundation.
Keywords
- Absorption
- Iontophoresis
- Kinetics
ASJC Scopus subject areas
- Pharmaceutical Science