We document evidence that the major rate-limiting step in iontophoretic drug delivery of low molecular weight charged solutes can be dermal perfusion at the site of application; for high molecular weight solutes, on the other hand, transport to the site of microcirculation uptake may, in some circumstances, become the slowest step.

Original languageEnglish
Pages (from-to)R1-R5
JournalInternational Journal of Pharmaceutics
Issue number3
Publication statusPublished - 25 Jan 1994

Bibliographical note

Funding Information:
Supportedi n part by a grantf rom the National Instituteso f Health (HD-27839)t o R.H.G.M.S.R. acknowledgesth e support of National Health & Medical Research Council of Australia and the Queenslanda nd Northern New South Wales Lions and Kidney Medical ResearchF oundation.


  • Absorption
  • Iontophoresis
  • Kinetics

ASJC Scopus subject areas

  • Pharmaceutical Science


Dive into the research topics of 'What is the transport-limiting barrier in iontophoresis?'. Together they form a unique fingerprint.

Cite this