What is the transport-limiting barrier in iontophoresis?

P. Singh; R. H. Guy; M. S. Roberts; H. I. Maibach

doi:10.1016/0378-5173(94)90225-9

What is the transport-limiting barrier in iontophoresis?

P. Singh, R. H. Guy, M. S. Roberts, H. I. Maibach

Research output: Contribution to journal › Article › peer-review

Abstract

We document evidence that the major rate-limiting step in iontophoretic drug delivery of low molecular weight charged solutes can be dermal perfusion at the site of application; for high molecular weight solutes, on the other hand, transport to the site of microcirculation uptake may, in some circumstances, become the slowest step.

Original language	English
Pages (from-to)	R1-R5
Journal	International Journal of Pharmaceutics
Volume	101
Issue number	3
DOIs	https://doi.org/10.1016/0378-5173(94)90225-9
Publication status	Published - 25 Jan 1994

Keywords

Absorption
Iontophoresis
Kinetics

ASJC Scopus subject areas

Pharmaceutical Science

Access to Document

10.1016/0378-5173(94)90225-9

Cite this

@article{8cbdfdf67753455fab81e85aac85f9e9,

title = "What is the transport-limiting barrier in iontophoresis?",

abstract = "We document evidence that the major rate-limiting step in iontophoretic drug delivery of low molecular weight charged solutes can be dermal perfusion at the site of application; for high molecular weight solutes, on the other hand, transport to the site of microcirculation uptake may, in some circumstances, become the slowest step.",

keywords = "Absorption, Iontophoresis, Kinetics",

author = "P. Singh and Guy, {R. H.} and Roberts, {M. S.} and Maibach, {H. I.}",

note = "Funding Information: Supportedi n part by a grantf rom the National Instituteso f Health (HD-27839)t o R.H.G.M.S.R. acknowledgesth e support of National Health & Medical Research Council of Australia and the Queenslanda nd Northern New South Wales Lions and Kidney Medical ResearchF oundation.",

year = "1994",

month = jan,

day = "25",

doi = "10.1016/0378-5173(94)90225-9",

language = "English",

volume = "101",

pages = "R1--R5",

journal = "International Journal of Pharmaceutics",

issn = "0378-5173",