Well-controlled synthesis of boronic-acid functionalised poly(lactide)s: a versatile platform for biocompatible polymer conjugates and sensors

Alison J. Cross; Matthew G. Davidson; Daniel García-vivó; Tony D. James

doi:10.1039/c2ra20373a

Well-controlled synthesis of boronic-acid functionalised poly(lactide)s: a versatile platform for biocompatible polymer conjugates and sensors

Alison J. Cross, Matthew G. Davidson, Daniel García-vivó, Tony D. James

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

15 Citations (SciVal)

Abstract

We report the controlled synthesis of boronic-acid terminated polylactides via the use of a protected boronic acid-functionalised ring-opening polymerisation initiator and the subsequent deprotection of the resultant polymer. We have demonstrated the utility of this approach to biocompatible polymer conjugates of biologically-relevant diols using an indicator- displacement assay.

Original language	English
Pages (from-to)	5954-5956
Journal	RSC Advances
Volume	2
Issue number	14
DOIs	https://doi.org/10.1039/c2ra20373a
Publication status	Published - 1 Jan 2012

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title = "Well-controlled synthesis of boronic-acid functionalised poly(lactide)s: a versatile platform for biocompatible polymer conjugates and sensors",

abstract = "We report the controlled synthesis of boronic-acid terminated polylactides via the use of a protected boronic acid-functionalised ring-opening polymerisation initiator and the subsequent deprotection of the resultant polymer. We have demonstrated the utility of this approach to biocompatible polymer conjugates of biologically-relevant diols using an indicator- displacement assay. ",

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AU - Cross, Alison J.

AU - Davidson, Matthew G.

AU - García-vivó, Daniel

AU - James, Tony D.

PY - 2012/1/1

Y1 - 2012/1/1

N2 - We report the controlled synthesis of boronic-acid terminated polylactides via the use of a protected boronic acid-functionalised ring-opening polymerisation initiator and the subsequent deprotection of the resultant polymer. We have demonstrated the utility of this approach to biocompatible polymer conjugates of biologically-relevant diols using an indicator- displacement assay.

AB - We report the controlled synthesis of boronic-acid terminated polylactides via the use of a protected boronic acid-functionalised ring-opening polymerisation initiator and the subsequent deprotection of the resultant polymer. We have demonstrated the utility of this approach to biocompatible polymer conjugates of biologically-relevant diols using an indicator- displacement assay.

UR - https://www.scopus.com/pages/publications/84862985319

UR - http://dx.doi.org/10.1039/c2ra20373a

U2 - 10.1039/c2ra20373a

DO - 10.1039/c2ra20373a

M3 - Article

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JO - RSC Advances

JF - RSC Advances

IS - 14

ER -

Well-controlled synthesis of boronic-acid functionalised poly(lactide)s: a versatile platform for biocompatible polymer conjugates and sensors

Abstract

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