WDR55 is a nucleolar modulator of ribosomal RNA synthesis, cell cycle progression, and teleost organ development

Norimasa Iwanami, Tomokazu Higuchi, Yumi Sasano, Toshinobu Fujiwara, Vu Q Hoa, Minoru Okada, Sadiqur R Talukder, Sanae Kunimatsu, Jie Li, Fumi Saito, Chitralekha Bhattacharya, Angabin Matin, Takashi Sasaki, Nobuyoshi Shimizu, Hiroshi Mitani, Heinz Himmelbauer, Akihiro Momoi, Hisato Kondoh, Makoto Furutani-Seiki, Yousuke Takahama

Research output: Contribution to journalArticlepeer-review

20 Citations (SciVal)


The thymus is a vertebrate-specific organ where T lymphocytes are generated. Genetic programs that lead to thymus development are incompletely understood. We previously screened ethylnitrosourea-induced medaka mutants for recessive defects in thymus development. Here we report that one of those mutants is caused by a missense mutation in a gene encoding the previously uncharacterized protein WDR55 carrying the tryptophan-aspartate-repeat motif. We find that WDR55 is a novel nucleolar protein involved in the production of ribosomal RNA (rRNA). Defects in WDR55 cause aberrant accumulation of rRNA intermediates and cell cycle arrest. A mutation in WDR55 in zebrafish also leads to analogous defects in thymus development, whereas WDR55-null mice are lethal before implantation. These results indicate that WDR55 is a nuclear modulator of rRNA synthesis, cell cycle progression, and embryonic organogenesis including teleost thymus development.
Original languageEnglish
Article numbere1000171
Number of pages13
JournalPlos Genetics
Issue number8
Publication statusPublished - 29 Aug 2008

Bibliographical note

Erratum in: PLoS Genet. 2008 Sep;4(9). doi: 10.1371/annotation/6683988c-4647-4550-88e3-e8ba052f7916


Dive into the research topics of 'WDR55 is a nucleolar modulator of ribosomal RNA synthesis, cell cycle progression, and teleost organ development'. Together they form a unique fingerprint.

Cite this