Wastewater-based epidemiology for the assessment of population exposure to chemicals: The need for integration with human biomonitoring for global One Health actions

Barbara Kasprzyk-Hordern; Frederic Béen; Lubertus Bijlsma; Werner Brack; Sara Castiglioni; Adrian Covaci; Bice S Martincigh; Jochen F Mueller; Alexander L N van Nuijs; Temilola Oluseyi; Kevin V Thomas

doi:10.1016/j.jhazmat.2023.131009

Wastewater-based epidemiology for the assessment of population exposure to chemicals: The need for integration with human biomonitoring for global One Health actions

Barbara Kasprzyk-Hordern, Frederic Béen, Lubertus Bijlsma, Werner Brack, Sara Castiglioni, Adrian Covaci, Bice S Martincigh, Jochen F Mueller, Alexander L N van Nuijs, Temilola Oluseyi, Kevin V Thomas

Research output: Contribution to journal › Article › peer-review

23 Citations (SciVal)

Abstract

WBE has now become a complimentary tool in SARS-CoV-2 surveillance. This was preceded by the established application of WBE to assess the consumption of illicit drugs in communities. It is now timely to build on this and take the opportunity to expand WBE to enable comprehensive assessment of community exposure to chemical stressors and their mixtures. The goal of WBE is to quantify community exposure, discover exposure-outcome associations, and trigger policy, technological or societal intervention strategies with the overarching aim of exposure prevention and public health promotion. To achieve WBE's full potential, the following key aspects require further action: (1) Integration of WBE-HBM (human biomonitoring) initiatives that provide comprehensive community-individual multichemical exposure assessment. (2) Global WBE monitoring campaigns to provide much needed data on exposure in low- and middle-income countries (LMICs) and fill in the gaps in knowledge especially in the underrepresented highly urbanised as well as rural settings in LMICs. (3) Combining WBE with One Health actions to enable effective interventions. (4) Advancements in new analytical tools and methodologies for WBE progression to enable biomarker selection for exposure studies, and to provide sensitive and selective multiresidue analysis for trace multi-biomarker quantification in a complex wastewater matrix. Most of all, further developments of WBE needs to be undertaken by co-design with key stakeholder groups: government organisations, health authorities and private sector.

Original language	English
Article number	131009
Journal	Journal of Hazardous Materials
Volume	450
Early online date	14 Feb 2023
DOIs	https://doi.org/10.1016/j.jhazmat.2023.131009
Publication status	Published - 15 May 2023

Bibliographical note

Funding Information:
The authors would like to acknowledge support from the EU Interwaste Project ‘Synergising International Research Studies into the Environmental Fate and Behaviour of Toxic Organic Chemicals in the Waste Stream’ (Grant agreement ID: 734522). L. Bijlsma acknowledges that the project that gave rise to these results received the support of a fellowship from “la Caixa” Foundation (ID 10 0 010434). The fellowship code is LCF/BQ/PR21/11840012. He also acknowledges grant RYC2020-028936-I funded by MCIN/AEI/ 10.13039/501100011033 and by “ESF Investing in Your Future”. Support from Engineering and Physical Sciences Research Council (EP/V028499/1) is also appreciated.

Data availability
No data was used for the research described in the artic

Funding

The authors would like to acknowledge support from the EU Interwaste Project ‘Synergising International Research Studies into the Environmental Fate and Behaviour of Toxic Organic Chemicals in the Waste Stream’ (Grant agreement ID: 734522 ). L. Bijlsma acknowledges that the project that gave rise to these results received the support of a fellowship from “la Caixa” Foundation (ID 10 0 010434 ). The fellowship code is LCF/BQ/PR21/11840012. He also acknowledges grant RYC2020-028936-I funded by MCIN/AEI / 10.13039/501100011033 and by “ESF Investing in Your Future” . Support from Engineering and Physical Sciences Research Council ( EP/V028499/1 ) is also appreciated. The authors would like to acknowledge support from the EU Interwaste Project ‘Synergising International Research Studies into the Environmental Fate and Behaviour of Toxic Organic Chemicals in the Waste Stream’ (Grant agreement ID: 734522). L. Bijlsma acknowledges that the project that gave rise to these results received the support of a fellowship from “la Caixa” Foundation (ID 10 0 010434). The fellowship code is LCF/BQ/PR21/11840012. He also acknowledges grant RYC2020-028936-I funded by MCIN/AEI/ 10.13039/501100011033 and by “ESF Investing in Your Future”. Support from Engineering and Physical Sciences Research Council (EP/V028499/1) is also appreciated.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Human Biomonitoring (HBM)
Human chemical exposure
Mass spectrometry
One Health
Wastewater-Based Epidemiology (WBE)

ASJC Scopus subject areas

Pollution
Waste Management and Disposal
Health, Toxicology and Mutagenesis
Environmental Engineering
Environmental Chemistry

Access to Document

10.1016/j.jhazmat.2023.131009

Cite this

Kasprzyk-Hordern, B., Béen, F., Bijlsma, L., Brack, W., Castiglioni, S., Covaci, A., Martincigh, B. S., Mueller, J. F., van Nuijs, A. L. N., Oluseyi, T., & Thomas, K. V. (2023). Wastewater-based epidemiology for the assessment of population exposure to chemicals: The need for integration with human biomonitoring for global One Health actions. Journal of Hazardous Materials, 450, Article 131009. https://doi.org/10.1016/j.jhazmat.2023.131009

Wastewater-based epidemiology for the assessment of population exposure to chemicals: The need for integration with human biomonitoring for global One Health actions. / Kasprzyk-Hordern, Barbara; Béen, Frederic; Bijlsma, Lubertus et al.
In: Journal of Hazardous Materials, Vol. 450, 131009, 15.05.2023.

Research output: Contribution to journal › Article › peer-review

Kasprzyk-Hordern, B, Béen, F, Bijlsma, L, Brack, W, Castiglioni, S, Covaci, A, Martincigh, BS, Mueller, JF, van Nuijs, ALN, Oluseyi, T & Thomas, KV 2023, 'Wastewater-based epidemiology for the assessment of population exposure to chemicals: The need for integration with human biomonitoring for global One Health actions', Journal of Hazardous Materials, vol. 450, 131009. https://doi.org/10.1016/j.jhazmat.2023.131009

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title = "Wastewater-based epidemiology for the assessment of population exposure to chemicals: The need for integration with human biomonitoring for global One Health actions",

abstract = "WBE has now become a complimentary tool in SARS-CoV-2 surveillance. This was preceded by the established application of WBE to assess the consumption of illicit drugs in communities. It is now timely to build on this and take the opportunity to expand WBE to enable comprehensive assessment of community exposure to chemical stressors and their mixtures. The goal of WBE is to quantify community exposure, discover exposure-outcome associations, and trigger policy, technological or societal intervention strategies with the overarching aim of exposure prevention and public health promotion. To achieve WBE's full potential, the following key aspects require further action: (1) Integration of WBE-HBM (human biomonitoring) initiatives that provide comprehensive community-individual multichemical exposure assessment. (2) Global WBE monitoring campaigns to provide much needed data on exposure in low- and middle-income countries (LMICs) and fill in the gaps in knowledge especially in the underrepresented highly urbanised as well as rural settings in LMICs. (3) Combining WBE with One Health actions to enable effective interventions. (4) Advancements in new analytical tools and methodologies for WBE progression to enable biomarker selection for exposure studies, and to provide sensitive and selective multiresidue analysis for trace multi-biomarker quantification in a complex wastewater matrix. Most of all, further developments of WBE needs to be undertaken by co-design with key stakeholder groups: government organisations, health authorities and private sector.",

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note = "Funding Information: The authors would like to acknowledge support from the EU Interwaste Project {\textquoteleft}Synergising International Research Studies into the Environmental Fate and Behaviour of Toxic Organic Chemicals in the Waste Stream{\textquoteright} (Grant agreement ID: 734522). L. Bijlsma acknowledges that the project that gave rise to these results received the support of a fellowship from “la Caixa” Foundation (ID 10 0 010434). The fellowship code is LCF/BQ/PR21/11840012. He also acknowledges grant RYC2020-028936-I funded by MCIN/AEI/ 10.13039/501100011033 and by “ESF Investing in Your Future”. Support from Engineering and Physical Sciences Research Council (EP/V028499/1) is also appreciated. Data availability No data was used for the research described in the artic",

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AU - Kasprzyk-Hordern, Barbara

AU - Béen, Frederic

AU - Bijlsma, Lubertus

AU - Brack, Werner

AU - Castiglioni, Sara

AU - Covaci, Adrian

AU - Martincigh, Bice S

AU - Mueller, Jochen F

AU - van Nuijs, Alexander L N

AU - Oluseyi, Temilola

AU - Thomas, Kevin V

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KW - Mass spectrometry

KW - One Health

KW - Wastewater-Based Epidemiology (WBE)

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Wastewater-based epidemiology for the assessment of population exposure to chemicals: The need for integration with human biomonitoring for global One Health actions

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

UKRI GCRF/Newton Fund : Building an Early Warning System for community-wide infectious disease spread: SARS-CoV-2 tracking in Africa via environment fingerprinting- COVID-19

ReNEW

Cite this

Wastewater-based epidemiology for the assessment of population exposure to chemicals: The need for integration with human biomonitoring for global One Health actions

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Projects

UKRI GCRF/Newton Fund : Building an Early Warning System for community-wide infectious disease spread: SARS-CoV-2 tracking in Africa via environment fingerprinting- COVID-19

ReNEW

Cite this