Vulnerability of the brain to neuropsychiatric disorders resulting from abnormal thyroid hormone or vitamin D homeostasis

Sarah J Bailey, P J McCaffery

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Nutritional modification is an approach to augment protection of the brain from psychiatric disease that is both inexpensive and with fewer side-effects than most psychoactive drugs. Two factors derived from nutritional sources that regulate gene transcription via nuclear receptors are thyroid hormone and vitamin D. Both of these factors thus lie at a nexus of environmental and genetic regulation of gene expression. Changes in both pathways have been associated with schizophrenia and depression but unlike dietary supplements such as omega-3 fatty acids, their mode of signalling is well understood. This chapter details the association of thyroid hormone and vitamin D with these psychiatric disorders. Likely targets for these two nuclear receptor regulators include the dopamine receptors, serotonergic pathways, hippocampal neurogenesis as well as components of the developing brain. The association of the nuclear receptor signalling pathways with several diseases suggests that they are less likely to be responsible for the unique features of each disease but are involved in aspects common to the disorders, as has been proposed for genes such as DISC1. An imbalance in the thyroid hormone and vitamin D pathways may contribute to depression and schizophrenia and restoration of homeostasis may provide a route by which the brain may be protected.
Original languageEnglish
Title of host publicationBrain Protection in Schizophrenia, Mood and Cognitive Disorders
EditorsM Ritsner
Place of PublicationNetherlands
PublisherSpringer
Pages105-133
Number of pages29
ISBN (Print)978-90-481-8552-8
DOIs
Publication statusPublished - 2010

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Cytoplasmic and Nuclear Receptors
Thyroid Hormones
Vitamin D
Homeostasis
Psychiatry
Schizophrenia
Brain
Depression
Psychotropic Drugs
Neurogenesis
Dopamine Receptors
Omega-3 Fatty Acids
Gene Expression Regulation
Brain Diseases
Dietary Supplements
Genes

Cite this

Bailey, S. J., & McCaffery, P. J. (2010). Vulnerability of the brain to neuropsychiatric disorders resulting from abnormal thyroid hormone or vitamin D homeostasis. In M. Ritsner (Ed.), Brain Protection in Schizophrenia, Mood and Cognitive Disorders (pp. 105-133). Netherlands: Springer. https://doi.org/10.1007/978-90-481-8553-5_5

Vulnerability of the brain to neuropsychiatric disorders resulting from abnormal thyroid hormone or vitamin D homeostasis. / Bailey, Sarah J; McCaffery, P J.

Brain Protection in Schizophrenia, Mood and Cognitive Disorders. ed. / M Ritsner. Netherlands : Springer, 2010. p. 105-133.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bailey, SJ & McCaffery, PJ 2010, Vulnerability of the brain to neuropsychiatric disorders resulting from abnormal thyroid hormone or vitamin D homeostasis. in M Ritsner (ed.), Brain Protection in Schizophrenia, Mood and Cognitive Disorders. Springer, Netherlands, pp. 105-133. https://doi.org/10.1007/978-90-481-8553-5_5
Bailey SJ, McCaffery PJ. Vulnerability of the brain to neuropsychiatric disorders resulting from abnormal thyroid hormone or vitamin D homeostasis. In Ritsner M, editor, Brain Protection in Schizophrenia, Mood and Cognitive Disorders. Netherlands: Springer. 2010. p. 105-133 https://doi.org/10.1007/978-90-481-8553-5_5
Bailey, Sarah J ; McCaffery, P J. / Vulnerability of the brain to neuropsychiatric disorders resulting from abnormal thyroid hormone or vitamin D homeostasis. Brain Protection in Schizophrenia, Mood and Cognitive Disorders. editor / M Ritsner. Netherlands : Springer, 2010. pp. 105-133
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