Visualization of the crystallization of lactose from the amorphous state

R Price, P M Young

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Abstract

The physical stability and solid-state recrystallization of spray-dried 'amorphous' lactose particles were visualized using environmentally controlled atomic force microscopy (EC-AFM) and conventional optical microscopy. The morphology and crystalline state were investigated as a function of relative humidity (RH) and were correlated with bulk gravimetric vapor sorption measurements that were run in parallel. The metastable nature of amorphous spray-dried lactose particles was apparent at low RHs (
Original languageEnglish
Pages (from-to)155-164
Number of pages10
JournalJournal of Pharmaceutical Sciences
Volume93
Issue number1
DOIs
Publication statusPublished - 2004

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