Visualization of penicillin G acylase in bacteria and high-throughput screening of natural inhibitors using a ratiometric fluorescent probe

Lu Li, Lei Feng, Ming Zhang, Xin He, Shengqiao Luan, Chao Wang, Tony D. James, Houli Zhang, Huilian Huang, Xiaochi Ma

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

A ratiometric fluorescent probe (PNA) was developed to sense and image endogenous bacterial penicillin G acylase (PGA). Oleanolic acid was discovered as a potential natural inhibitor of PGA using high-throughput screening techniques based on PNA.

Original languageEnglish
Pages (from-to)4640-4643
Number of pages4
JournalChemical communications (Cambridge, England)
Volume56
Issue number34
DOIs
Publication statusPublished - 24 Apr 2020

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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