Vascular Regenerative Surgery: Promised Land for Tissue Engineers?

T. Fortunato, P. De Bank, G Pula

Research output: Contribution to journalArticle

78 Downloads (Pure)

Abstract

Cardiovascular cell therapy is a promising new field for the development of treatments for cardiovascular diseases, which remain a major cause of mortality around the world. In this review, we highlight the options currently available for the development of specific cell therapy approaches applied to regeneration of cardiac and vascular tissues. Different cell types have attracted a lot of attention and extensive investigations for the treatment of vascular diseases, including embryonic stem cells, mesenchymal stem cells, induced pluripotent stem cells, and endothelial progenitors. The combination of human cells and increasingly safe and physiologically compliant biomaterials is currently offering an unprecedented opportunity to develop effective cell therapy for either major blood vessels or the microvasculature. Efficacy and safety of cell therapy
are the challenges for the new generation of regenerative medicine scientists determined to develop new remedies for cardiovascular diseases. Here we present the state of the art in this biomedical field and the options in terms of cell types and biomaterials currently available for cardiovascular cell therapy.
Original languageEnglish
Pages (from-to)268-276
JournalInternational Journal of Stem Cell Research and Transplantation
Volume5
Issue number2
DOIs
Publication statusPublished - 3 Jun 2017

Fingerprint

Cell- and Tissue-Based Therapy
Blood Vessels
Biocompatible Materials
Cardiovascular Diseases
Induced Pluripotent Stem Cells
Regenerative Medicine
Embryonic Stem Cells
Microvessels
Mesenchymal Stromal Cells
Vascular Diseases
Regeneration
Safety
Mortality
Therapeutics

Cite this

Vascular Regenerative Surgery: Promised Land for Tissue Engineers? / Fortunato, T.; De Bank, P.; Pula, G.

In: International Journal of Stem Cell Research and Transplantation, Vol. 5, No. 2, 03.06.2017, p. 268-276.

Research output: Contribution to journalArticle

@article{5454a07389be40738c3e4bea20189b6c,
title = "Vascular Regenerative Surgery: Promised Land for Tissue Engineers?",
abstract = "Cardiovascular cell therapy is a promising new field for the development of treatments for cardiovascular diseases, which remain a major cause of mortality around the world. In this review, we highlight the options currently available for the development of specific cell therapy approaches applied to regeneration of cardiac and vascular tissues. Different cell types have attracted a lot of attention and extensive investigations for the treatment of vascular diseases, including embryonic stem cells, mesenchymal stem cells, induced pluripotent stem cells, and endothelial progenitors. The combination of human cells and increasingly safe and physiologically compliant biomaterials is currently offering an unprecedented opportunity to develop effective cell therapy for either major blood vessels or the microvasculature. Efficacy and safety of cell therapyare the challenges for the new generation of regenerative medicine scientists determined to develop new remedies for cardiovascular diseases. Here we present the state of the art in this biomedical field and the options in terms of cell types and biomaterials currently available for cardiovascular cell therapy.",
author = "T. Fortunato and {De Bank}, P. and G Pula",
year = "2017",
month = "6",
day = "3",
doi = "10.19070/2328-3548-1700041",
language = "English",
volume = "5",
pages = "268--276",
journal = "International Journal of Stem Cell Research and Transplantation",
issn = "2328-3548",
number = "2",

}

TY - JOUR

T1 - Vascular Regenerative Surgery: Promised Land for Tissue Engineers?

AU - Fortunato, T.

AU - De Bank, P.

AU - Pula, G

PY - 2017/6/3

Y1 - 2017/6/3

N2 - Cardiovascular cell therapy is a promising new field for the development of treatments for cardiovascular diseases, which remain a major cause of mortality around the world. In this review, we highlight the options currently available for the development of specific cell therapy approaches applied to regeneration of cardiac and vascular tissues. Different cell types have attracted a lot of attention and extensive investigations for the treatment of vascular diseases, including embryonic stem cells, mesenchymal stem cells, induced pluripotent stem cells, and endothelial progenitors. The combination of human cells and increasingly safe and physiologically compliant biomaterials is currently offering an unprecedented opportunity to develop effective cell therapy for either major blood vessels or the microvasculature. Efficacy and safety of cell therapyare the challenges for the new generation of regenerative medicine scientists determined to develop new remedies for cardiovascular diseases. Here we present the state of the art in this biomedical field and the options in terms of cell types and biomaterials currently available for cardiovascular cell therapy.

AB - Cardiovascular cell therapy is a promising new field for the development of treatments for cardiovascular diseases, which remain a major cause of mortality around the world. In this review, we highlight the options currently available for the development of specific cell therapy approaches applied to regeneration of cardiac and vascular tissues. Different cell types have attracted a lot of attention and extensive investigations for the treatment of vascular diseases, including embryonic stem cells, mesenchymal stem cells, induced pluripotent stem cells, and endothelial progenitors. The combination of human cells and increasingly safe and physiologically compliant biomaterials is currently offering an unprecedented opportunity to develop effective cell therapy for either major blood vessels or the microvasculature. Efficacy and safety of cell therapyare the challenges for the new generation of regenerative medicine scientists determined to develop new remedies for cardiovascular diseases. Here we present the state of the art in this biomedical field and the options in terms of cell types and biomaterials currently available for cardiovascular cell therapy.

UR - https://doi.org/10.19070/2328-3548-1700041

U2 - 10.19070/2328-3548-1700041

DO - 10.19070/2328-3548-1700041

M3 - Article

VL - 5

SP - 268

EP - 276

JO - International Journal of Stem Cell Research and Transplantation

JF - International Journal of Stem Cell Research and Transplantation

SN - 2328-3548

IS - 2

ER -