Vascular physiology and pathology of circulating xanthine oxidoreductase: from nucleotide sequence to functional enzyme

J Hewinson, C R Stevens, T M Millar

Research output: Contribution to journalArticle

11 Citations (Scopus)


The evolutionarily conserved, cofactor-dependent, enzyme xanthine oxidoreductase exists in both cell-associated and circulatory forms. The exact role of the circulating form is not known; however, several putative physiological and pathological functions have been suggested that range from purine catabolism to a mediator of acute respiratory distress syndrome. Regulation of gene expression, cofactor synthesis and insertion, post-translational conversion, entry into the circulation, and putative physiological and pathological roles for human circulating xanthine oxidoreductase are discussed.
Original languageEnglish
Pages (from-to)71-79
Number of pages9
JournalRedox Report
Issue number2
Publication statusPublished - 2004


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