Vascular and Alzheimer's disease markers independently predict brain atrophy rate in Alzheimer's Disease Neuroimaging Initiative controls

Alzheimer's Disease Neuroimaging Initiative

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

This study assessed relationships among white matter hyperintensities (WMH), cerebrospinal fluid (CSF), Alzheimer's disease (AD) pathology markers, and brain volume loss. Subjects included 197 controls, 331 individuals with mild cognitive impairment (MCI), and 146 individuals with AD with serial volumetric 1.5-T MRI. CSF Aβ1-42 (n = 351) and tau (n = 346) were measured. Brain volume change was quantified using the boundary shift integral (BSI). We assessed the association between baseline WMH volume and annualized BSI, adjusting for intracranial volume. We also performed multiple regression analyses in the CSF subset, assessing the relationships of WMH and Aβ1-42 and/or tau with BSI. WMH burden was positively associated with BSI in controls (p = 0.02) but not MCI or AD. In multivariable models, WMH (p = 0.003) and Aβ1-42 (p = 0.001) were independently associated with BSI in controls; in MCI Aβ1-42 (p < 0.001) and tau (p = 0.04) were associated with BSI. There was no evidence of independent effects of WMH or CSF measures on BSI in AD. These data support findings that vascular damage is associated with increased brain atrophy in the context of AD pathology in pre-dementia stages.

Original languageEnglish
Pages (from-to)1996-2002
Number of pages7
JournalNeurobiology of Aging
Volume34
Issue number8
Early online date21 Mar 2013
DOIs
Publication statusPublished - 1 Aug 2013

Keywords

  • Aged
  • Alzheimer Disease/cerebrospinal fluid
  • Amyloid beta-Peptides/cerebrospinal fluid
  • Atrophy
  • Biomarkers/cerebrospinal fluid
  • Brain/metabolism
  • Cerebral Arteries/pathology
  • Cognitive Dysfunction/cerebrospinal fluid
  • Disease Progression
  • Female
  • Functional Neuroimaging
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Peptide Fragments/cerebrospinal fluid
  • tau Proteins/cerebrospinal fluid

Cite this

Vascular and Alzheimer's disease markers independently predict brain atrophy rate in Alzheimer's Disease Neuroimaging Initiative controls. / Alzheimer's Disease Neuroimaging Initiative.

In: Neurobiology of Aging, Vol. 34, No. 8, 01.08.2013, p. 1996-2002.

Research output: Contribution to journalArticle

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abstract = "This study assessed relationships among white matter hyperintensities (WMH), cerebrospinal fluid (CSF), Alzheimer's disease (AD) pathology markers, and brain volume loss. Subjects included 197 controls, 331 individuals with mild cognitive impairment (MCI), and 146 individuals with AD with serial volumetric 1.5-T MRI. CSF Aβ1-42 (n = 351) and tau (n = 346) were measured. Brain volume change was quantified using the boundary shift integral (BSI). We assessed the association between baseline WMH volume and annualized BSI, adjusting for intracranial volume. We also performed multiple regression analyses in the CSF subset, assessing the relationships of WMH and Aβ1-42 and/or tau with BSI. WMH burden was positively associated with BSI in controls (p = 0.02) but not MCI or AD. In multivariable models, WMH (p = 0.003) and Aβ1-42 (p = 0.001) were independently associated with BSI in controls; in MCI Aβ1-42 (p < 0.001) and tau (p = 0.04) were associated with BSI. There was no evidence of independent effects of WMH or CSF measures on BSI in AD. These data support findings that vascular damage is associated with increased brain atrophy in the context of AD pathology in pre-dementia stages.",
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T1 - Vascular and Alzheimer's disease markers independently predict brain atrophy rate in Alzheimer's Disease Neuroimaging Initiative controls

AU - Alzheimer's Disease Neuroimaging Initiative

AU - Barnes, Josephine

AU - Carmichael, Owen T

AU - Leung, Kelvin K

AU - Schwarz, Christopher

AU - Ridgway, Gerard R

AU - Bartlett, Jonathan W

AU - Malone, Ian B

AU - Schott, Jonathan M

AU - Rossor, Martin N

AU - Biessels, Geert Jan

AU - DeCarli, Charlie

AU - Fox, Nick C

N1 - Copyright © 2013 Elsevier Inc. All rights reserved.

PY - 2013/8/1

Y1 - 2013/8/1

N2 - This study assessed relationships among white matter hyperintensities (WMH), cerebrospinal fluid (CSF), Alzheimer's disease (AD) pathology markers, and brain volume loss. Subjects included 197 controls, 331 individuals with mild cognitive impairment (MCI), and 146 individuals with AD with serial volumetric 1.5-T MRI. CSF Aβ1-42 (n = 351) and tau (n = 346) were measured. Brain volume change was quantified using the boundary shift integral (BSI). We assessed the association between baseline WMH volume and annualized BSI, adjusting for intracranial volume. We also performed multiple regression analyses in the CSF subset, assessing the relationships of WMH and Aβ1-42 and/or tau with BSI. WMH burden was positively associated with BSI in controls (p = 0.02) but not MCI or AD. In multivariable models, WMH (p = 0.003) and Aβ1-42 (p = 0.001) were independently associated with BSI in controls; in MCI Aβ1-42 (p < 0.001) and tau (p = 0.04) were associated with BSI. There was no evidence of independent effects of WMH or CSF measures on BSI in AD. These data support findings that vascular damage is associated with increased brain atrophy in the context of AD pathology in pre-dementia stages.

AB - This study assessed relationships among white matter hyperintensities (WMH), cerebrospinal fluid (CSF), Alzheimer's disease (AD) pathology markers, and brain volume loss. Subjects included 197 controls, 331 individuals with mild cognitive impairment (MCI), and 146 individuals with AD with serial volumetric 1.5-T MRI. CSF Aβ1-42 (n = 351) and tau (n = 346) were measured. Brain volume change was quantified using the boundary shift integral (BSI). We assessed the association between baseline WMH volume and annualized BSI, adjusting for intracranial volume. We also performed multiple regression analyses in the CSF subset, assessing the relationships of WMH and Aβ1-42 and/or tau with BSI. WMH burden was positively associated with BSI in controls (p = 0.02) but not MCI or AD. In multivariable models, WMH (p = 0.003) and Aβ1-42 (p = 0.001) were independently associated with BSI in controls; in MCI Aβ1-42 (p < 0.001) and tau (p = 0.04) were associated with BSI. There was no evidence of independent effects of WMH or CSF measures on BSI in AD. These data support findings that vascular damage is associated with increased brain atrophy in the context of AD pathology in pre-dementia stages.

KW - Aged

KW - Alzheimer Disease/cerebrospinal fluid

KW - Amyloid beta-Peptides/cerebrospinal fluid

KW - Atrophy

KW - Biomarkers/cerebrospinal fluid

KW - Brain/metabolism

KW - Cerebral Arteries/pathology

KW - Cognitive Dysfunction/cerebrospinal fluid

KW - Disease Progression

KW - Female

KW - Functional Neuroimaging

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Peptide Fragments/cerebrospinal fluid

KW - tau Proteins/cerebrospinal fluid

U2 - 10.1016/j.neurobiolaging.2013.02.003

DO - 10.1016/j.neurobiolaging.2013.02.003

M3 - Article

VL - 34

SP - 1996

EP - 2002

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 1558-1497

IS - 8

ER -