UVA-Triggered Drug Release and Photo-Protection of Skin

Vega Widya Karisma; Wei Wu; Mingxing  Lei; Huawen  Liu; Muhammad Farrukh  Nisar; Matthew Lloyd; Charareh Pourzand; Julia Li Zhong

doi:10.3389/fcell.2021.598717

UVA-Triggered Drug Release and Photo-Protection of Skin

Vega Widya Karisma, Wei Wu, Mingxing Lei, Huawen Liu, Muhammad Farrukh Nisar, Matthew Lloyd, Charareh Pourzand, Julia Li Zhong

Research output: Contribution to journal › Review article › peer-review

24 Citations (SciVal)

Abstract

Light has attracted special attention as a stimulus for triggered drug delivery systems (DDS) due to its intrinsic features of being spatially and temporally tunable. Ultraviolet A (UVA) radiation has recently been used as a source of external light stimuli to control the release of drugs using a “switch on- switch off” procedure. This review discusses the promising potential of UVA radiation as the light source of choice for photo-controlled drug release from a range of photo-responsive and photolabile nanostructures via photo-isomerization, photo-cleavage, photo-crosslinking and photo-induced rearrangement. In addition to its clinical use, we will also provide here an overview of the recent UVA-responsive drug release approaches that are developed for phototherapy and skin photoprotection.

Original language	English
Article number	598717
Journal	Frontiers in Cell and Developmental Biology
Volume	9
DOIs	https://doi.org/10.3389/fcell.2021.598717
Publication status	Published - 11 Feb 2021

Bibliographical note

Funding Information:
This work is financially supported by The National Science Foundation of China (No. 82003384, 81271776,

Funding Information:
Funding. This work is financially supported by The National Science Foundation of China (No. 82003384, 81271776, and 81573073), The Fundamental Research Funds for the Central Universities (Project No. 2020CDJYGSG001 and 2020CDJYGSG003), Chongqing Talents Program (CQYC2020058022), Scientific Research Foundation from Chongqing University (02210011044110), and the 111 Project of Biomechanics and Tissue Repair (B605). This work was also supported by Series of Evidence-Based Study on Hot Spring Wellness, Chongqing Municipal Commission of Culture and Tourism Development (to JZ). Key projects of Chongqing Municipal Science and Technology Commission (cstc2017jcyjbx0044), and a Welcome Trust Showcase Award, UK (Contract No. 067653/Z/02/Z), and a Biotechnology and Biological Sciences Research Council (BBSRC, Grant No. BB/J005223/1), UK.

Publisher Copyright:
© Copyright © 2021 Karisma, Wu, Lei, Liu, Nisar, Lloyd, Pourzand and Zhong.

Keywords

UVA-triggered drug release
caged iron chelators
drug delivery systems (DDS)
skin photo-protection
smart sunscreens
up-conversion nanoparticles

ASJC Scopus subject areas

Cell Biology
Developmental Biology

Access to Document

10.3389/fcell.2021.598717Licence: CC BY

https://www.frontiersin.org/articles/10.3389/fcell.2021.598717/abstractLicence: CC BY

Cite this

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title = "UVA-Triggered Drug Release and Photo-Protection of Skin",

abstract = "Light has attracted special attention as a stimulus for triggered drug delivery systems (DDS) due to its intrinsic features of being spatially and temporally tunable. Ultraviolet A (UVA) radiation has recently been used as a source of external light stimuli to control the release of drugs using a “switch on- switch off” procedure. This review discusses the promising potential of UVA radiation as the light source of choice for photo-controlled drug release from a range of photo-responsive and photolabile nanostructures via photo-isomerization, photo-cleavage, photo-crosslinking and photo-induced rearrangement. In addition to its clinical use, we will also provide here an overview of the recent UVA-responsive drug release approaches that are developed for phototherapy and skin photoprotection.",

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author = "Karisma, {Vega Widya} and Wei Wu and Mingxing Lei and Huawen Liu and Nisar, {Muhammad Farrukh} and Matthew Lloyd and Charareh Pourzand and {Li Zhong}, Julia",

note = "Funding Information: This work is financially supported by The National Science Foundation of China (No. 82003384, 81271776, Funding Information: Funding. This work is financially supported by The National Science Foundation of China (No. 82003384, 81271776, and 81573073), The Fundamental Research Funds for the Central Universities (Project No. 2020CDJYGSG001 and 2020CDJYGSG003), Chongqing Talents Program (CQYC2020058022), Scientific Research Foundation from Chongqing University (02210011044110), and the 111 Project of Biomechanics and Tissue Repair (B605). This work was also supported by Series of Evidence-Based Study on Hot Spring Wellness, Chongqing Municipal Commission of Culture and Tourism Development (to JZ). Key projects of Chongqing Municipal Science and Technology Commission (cstc2017jcyjbx0044), and a Welcome Trust Showcase Award, UK (Contract No. 067653/Z/02/Z), and a Biotechnology and Biological Sciences Research Council (BBSRC, Grant No. BB/J005223/1), UK. Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Karisma, Wu, Lei, Liu, Nisar, Lloyd, Pourzand and Zhong.",

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AU - Lloyd, Matthew

AU - Pourzand, Charareh

AU - Li Zhong, Julia

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UVA-Triggered Drug Release and Photo-Protection of Skin

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Mitochondria-Targeted Iron Chelators for the Therapy of Parkinson's Disease

Light-Activated Caged-Iron Chelator for Skin Photoprotection based on the Natural Product Pulcherrimic Acid

Mitochondrial and Lysosomal-Targeted Iron Chelators for the Monitoring and Adjustment of Cellular Labile Iron Pools

Cite this

UVA-Triggered Drug Release and Photo-Protection of Skin

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Projects

Mitochondria-Targeted Iron Chelators for the Therapy of Parkinson's Disease

Light-Activated Caged-Iron Chelator for Skin Photoprotection based on the Natural Product Pulcherrimic Acid

Mitochondrial and Lysosomal-Targeted Iron Chelators for the Monitoring and Adjustment of Cellular Labile Iron Pools

Cite this