UVA-Triggered Drug Release and Photo-Protection of Skin

Vega Widya Karisma, Wei Wu, Mingxing Lei, Huawen Liu, Muhammad Farrukh Nisar, Matthew Lloyd, Charareh Pourzand, Julia Li Zhong

Research output: Contribution to journalReview articlepeer-review

14 Citations (SciVal)


Light has attracted special attention as a stimulus for triggered drug delivery systems (DDS) due to its intrinsic features of being spatially and temporally tunable. Ultraviolet A (UVA) radiation has recently been used as a source of external light stimuli to control the release of drugs using a “switch on- switch off” procedure. This review discusses the promising potential of UVA radiation as the light source of choice for photo-controlled drug release from a range of photo-responsive and photolabile nanostructures via photo-isomerization, photo-cleavage, photo-crosslinking and photo-induced rearrangement. In addition to its clinical use, we will also provide here an overview of the recent UVA-responsive drug release approaches that are developed for phototherapy and skin photoprotection.
Original languageEnglish
Article number598717
JournalFrontiers in Cell and Developmental Biology
Publication statusPublished - 11 Feb 2021

Bibliographical note

Funding Information:
This work is financially supported by The National Science Foundation of China (No. 82003384, 81271776,

Funding Information:
Funding. This work is financially supported by The National Science Foundation of China (No. 82003384, 81271776, and 81573073), The Fundamental Research Funds for the Central Universities (Project No. 2020CDJYGSG001 and 2020CDJYGSG003), Chongqing Talents Program (CQYC2020058022), Scientific Research Foundation from Chongqing University (02210011044110), and the 111 Project of Biomechanics and Tissue Repair (B605). This work was also supported by Series of Evidence-Based Study on Hot Spring Wellness, Chongqing Municipal Commission of Culture and Tourism Development (to JZ). Key projects of Chongqing Municipal Science and Technology Commission (cstc2017jcyjbx0044), and a Welcome Trust Showcase Award, UK (Contract No. 067653/Z/02/Z), and a Biotechnology and Biological Sciences Research Council (BBSRC, Grant No. BB/J005223/1), UK.

Publisher Copyright:
© Copyright © 2021 Karisma, Wu, Lei, Liu, Nisar, Lloyd, Pourzand and Zhong.


  • UVA-triggered drug release
  • caged iron chelators
  • drug delivery systems (DDS)
  • skin photo-protection
  • smart sunscreens
  • up-conversion nanoparticles

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology


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