with C3 degradation products in a natural way. We show that Sbi rapidly triggers the alternative complement pathway through recruitment of complement regulators, forming tripartite complexes that act as competitive antagonists of factor H, resulting in enhanced complement consumption. These functional results are corroborated by the structure of the complement activating Sbi-III-IV:C3d:FHR-1 complex. Finally, we demonstrate that Sbi, fused with Mycobacterium tuberculosis antigen Ag85b, causes efficient opsonisation with C3 fragments, thereby enhancing the immune response
significantly beyond that of Ag85b alone, providing proof of concept for our pro-vaccine approach.
- Immune evasion
- Staphycoccus aureus
ASJC Scopus subject areas
- Immunology and Allergy
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Person: Research & Teaching, Researcher
- Department of Life Sciences - Professor
- Centre for Sustainable and Circular Technologies (CSCT)
- Centre for Therapeutic Innovation
- Centre for Biosensors, Bioelectronics and Biodevices (C3Bio)
- Centre for Integrated Bioprocessing Research (CIBR)
- Milner Centre for Evolution
Person: Research & Teaching