Using genetic information to inform policy on cannabis

Lindsey A Hines, Jorien L Treur, Hannah J Jones, Hannah M Sallis, Marcus R Munafò

Research output: Contribution to journalArticle

4 Citations (SciVal)

Abstract

Cannabis is a commonly used drug, and a substantial minority of individuals who use it frequently will develop cannabis use disorder (CUD). Johnson and colleagues1 identify a high genetic correlation between liability to frequent cannabis use and CUD. This finding is in line with previous twin research, which has identified a high correlation between additive genetic influences acting on exposure to cannabis, frequency of cannabis use, and CUD.2 One straightforward interpretation is that frequent use is on the causal pathway to CUD; however, Johnson and colleagues1 do not explore this formally (eg, by using Mendelian randomisation, which uses genetic variants as proxies for exposures of interest).
Original languageEnglish
Pages (from-to)1002-1003
Number of pages2
JournalThe Lancet Psychiatry
Volume7
Issue number12
DOIs
Publication statusPublished - 31 Dec 2020

Keywords

  • Cannabis
  • Genome-Wide Association Study
  • Humans
  • Legislation, Drug
  • Marijuana Abuse
  • Policy

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