Use of the p-tolylsulfinyl group as a chiral inductor in stereoselective [4+3] cycloaddition reactions: preparation of enantiopure polysubstituted 8-oxabicyclo[3.2.1]oct-6-en-3-one systems having up to five stereocenters

A.M. Montaña, P.M. Grima, C. Batalla, F. Sanz, Gabriele Kociok-Kohn

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Abstract

The use of the p-tolylsulfinyl group as a chiral inductor in stereoselective [4+3] cycloaddition reactions has made possible the preparation of enantiopure polysubstituted 8-oxabicyclo[3.2.1]oct-6-en-3-one systems having up to five stereocenters. The presence in the furan diene of a susbtituent at the 3-position bearing an atom with lone-pair electrons propitiates the coordination of a metallic atom by the sulfoxide and the R "ligand" group. This chelation effect, together with the stereoelectronic demand of the R and sulfoxide groups, considerably decreases the degree of conformational freedom of the diene moiety in the cyclic transition state leading to the observed stereoselectivity. By choosing appropriate substituents in the furan ring, it is possible to obtain 100:0 cis-trans and 100:0 endo-exo diastereoselectivities. Up to 100% π-facial diastereoselectivity (enantioselectivity after removal of the sulfoxide group) could be reached. Yields lie within the range of 50-80%, depending on the furan substrate. However, if the furan diene is fitted with deactivating electron-withdrawing substituents, low conversions were observed under certain reaction conditions, but always with excellent-to-complete chemo- and stereoselectivities. The conversion and yield increase on introduction of an electron-donating substituent at the C-3 of the furan ring.
Original languageEnglish
Pages (from-to)2726-2746
Number of pages21
JournalEuropean Journal of Organic Chemistry
Volume2014
Issue number13
Early online date25 Apr 2014
DOIs
Publication statusPublished - 1 May 2014

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sulfoxide
Cycloaddition
furans
cycloaddition
inductors
dienes
preparation
Stereoselectivity
Electrons
Bearings (structural)
Atoms
chelation
electrons
Enantioselectivity
rings
Chelation
atoms
degrees of freedom
furan
Ligands

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title = "Use of the p-tolylsulfinyl group as a chiral inductor in stereoselective [4+3] cycloaddition reactions: preparation of enantiopure polysubstituted 8-oxabicyclo[3.2.1]oct-6-en-3-one systems having up to five stereocenters",
abstract = "The use of the p-tolylsulfinyl group as a chiral inductor in stereoselective [4+3] cycloaddition reactions has made possible the preparation of enantiopure polysubstituted 8-oxabicyclo[3.2.1]oct-6-en-3-one systems having up to five stereocenters. The presence in the furan diene of a susbtituent at the 3-position bearing an atom with lone-pair electrons propitiates the coordination of a metallic atom by the sulfoxide and the R {"}ligand{"} group. This chelation effect, together with the stereoelectronic demand of the R and sulfoxide groups, considerably decreases the degree of conformational freedom of the diene moiety in the cyclic transition state leading to the observed stereoselectivity. By choosing appropriate substituents in the furan ring, it is possible to obtain 100:0 cis-trans and 100:0 endo-exo diastereoselectivities. Up to 100{\%} π-facial diastereoselectivity (enantioselectivity after removal of the sulfoxide group) could be reached. Yields lie within the range of 50-80{\%}, depending on the furan substrate. However, if the furan diene is fitted with deactivating electron-withdrawing substituents, low conversions were observed under certain reaction conditions, but always with excellent-to-complete chemo- and stereoselectivities. The conversion and yield increase on introduction of an electron-donating substituent at the C-3 of the furan ring.",
author = "A.M. Monta{\~n}a and P.M. Grima and C. Batalla and F. Sanz and Gabriele Kociok-Kohn",
year = "2014",
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T2 - preparation of enantiopure polysubstituted 8-oxabicyclo[3.2.1]oct-6-en-3-one systems having up to five stereocenters

AU - Montaña, A.M.

AU - Grima, P.M.

AU - Batalla, C.

AU - Sanz, F.

AU - Kociok-Kohn, Gabriele

PY - 2014/5/1

Y1 - 2014/5/1

N2 - The use of the p-tolylsulfinyl group as a chiral inductor in stereoselective [4+3] cycloaddition reactions has made possible the preparation of enantiopure polysubstituted 8-oxabicyclo[3.2.1]oct-6-en-3-one systems having up to five stereocenters. The presence in the furan diene of a susbtituent at the 3-position bearing an atom with lone-pair electrons propitiates the coordination of a metallic atom by the sulfoxide and the R "ligand" group. This chelation effect, together with the stereoelectronic demand of the R and sulfoxide groups, considerably decreases the degree of conformational freedom of the diene moiety in the cyclic transition state leading to the observed stereoselectivity. By choosing appropriate substituents in the furan ring, it is possible to obtain 100:0 cis-trans and 100:0 endo-exo diastereoselectivities. Up to 100% π-facial diastereoselectivity (enantioselectivity after removal of the sulfoxide group) could be reached. Yields lie within the range of 50-80%, depending on the furan substrate. However, if the furan diene is fitted with deactivating electron-withdrawing substituents, low conversions were observed under certain reaction conditions, but always with excellent-to-complete chemo- and stereoselectivities. The conversion and yield increase on introduction of an electron-donating substituent at the C-3 of the furan ring.

AB - The use of the p-tolylsulfinyl group as a chiral inductor in stereoselective [4+3] cycloaddition reactions has made possible the preparation of enantiopure polysubstituted 8-oxabicyclo[3.2.1]oct-6-en-3-one systems having up to five stereocenters. The presence in the furan diene of a susbtituent at the 3-position bearing an atom with lone-pair electrons propitiates the coordination of a metallic atom by the sulfoxide and the R "ligand" group. This chelation effect, together with the stereoelectronic demand of the R and sulfoxide groups, considerably decreases the degree of conformational freedom of the diene moiety in the cyclic transition state leading to the observed stereoselectivity. By choosing appropriate substituents in the furan ring, it is possible to obtain 100:0 cis-trans and 100:0 endo-exo diastereoselectivities. Up to 100% π-facial diastereoselectivity (enantioselectivity after removal of the sulfoxide group) could be reached. Yields lie within the range of 50-80%, depending on the furan substrate. However, if the furan diene is fitted with deactivating electron-withdrawing substituents, low conversions were observed under certain reaction conditions, but always with excellent-to-complete chemo- and stereoselectivities. The conversion and yield increase on introduction of an electron-donating substituent at the C-3 of the furan ring.

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