Urinary bladder innervation within the sacral roots of a sheep

B. Metcalfe; N. Granger; J. Prager; L. Jabban; J. Taylor; S. Sadrafshari; N. Donaldson

doi:10.1109/NER49283.2021.9441117

Urinary bladder innervation within the sacral roots of a sheep

B. Metcalfe, N. Granger, J. Prager, L. Jabban, J. Taylor, S. Sadrafshari, N. Donaldson

Research output: Chapter or section in a book/report/conference proceeding › Chapter in a published conference proceeding

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Abstract

Managing the urinary bladder after spinal cord injury is of primary importance because neurogenic dysfunction leads to life-threatening complications. Sacral Anterior Root Stimulators that control the bladder have been available for many years, however, these devices cannot sense the fullness of the bladder or detect the onset of reflex voiding. In order to address this fundamental limitation, this paper explores the possibility of recording the neural signals that encode bladder fullness from the sacral roots in sheep using extra-neural books. Stimulation of and recording from six roots (S1, S2 and S3 bilaterally) shows that efferent and afferent pathways seem to be co-located within roots, but also that simultaneous recording from multiple roots may be useful to enhance overall signal quality.

Original language	English
Title of host publication	2021 10th International IEEE/EMBS Conference on Neural Engineering, NER 2021
Publisher	IEEE
Pages	605-608
Number of pages	4
ISBN (Electronic)	9781728143378
ISBN (Print)	978-1-7281-4338-5
DOIs	https://doi.org/10.1109/NER49283.2021.9441117
Publication status	Published - 2 Jun 2021
Event	10th International IEEE/EMBS Conference on Neural Engineering, NER 2021 - Virtual, Online, Italy Duration: 4 May 2021 → 6 May 2021

Publication series

Name	International IEEE/EMBS Conference on Neural Engineering, NER
Volume	2021-May
ISSN (Print)	1948-3546
ISSN (Electronic)	1948-3554

Conference

Conference	10th International IEEE/EMBS Conference on Neural Engineering, NER 2021
Country/Territory	Italy
City	Virtual, Online
Period	4/05/21 → 6/05/21

Bibliographical note

Funding Information:
* Research supported by the Engineering and Physical Sciences Research Council (EPSRC), UK via EP/P018947/1.

ASJC Scopus subject areas

Artificial Intelligence
Mechanical Engineering

Access to Document

10.1109/NER49283.2021.9441117

Metcalfe_NER2021 - Books_PDF
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Cite this

Metcalfe, B., Granger, N., Prager, J., Jabban, L., Taylor, J., Sadrafshari, S., & Donaldson, N. (2021). Urinary bladder innervation within the sacral roots of a sheep. In 2021 10th International IEEE/EMBS Conference on Neural Engineering, NER 2021 (pp. 605-608). Article 9441117 (International IEEE/EMBS Conference on Neural Engineering, NER; Vol. 2021-May). IEEE. https://doi.org/10.1109/NER49283.2021.9441117

Urinary bladder innervation within the sacral roots of a sheep. / Metcalfe, B.; Granger, N.; Prager, J. et al.
2021 10th International IEEE/EMBS Conference on Neural Engineering, NER 2021. IEEE, 2021. p. 605-608 9441117 (International IEEE/EMBS Conference on Neural Engineering, NER; Vol. 2021-May).

Research output: Chapter or section in a book/report/conference proceeding › Chapter in a published conference proceeding

Metcalfe, B, Granger, N, Prager, J, Jabban, L , Taylor, J , Sadrafshari, S & Donaldson, N 2021, Urinary bladder innervation within the sacral roots of a sheep. in 2021 10th International IEEE/EMBS Conference on Neural Engineering, NER 2021., 9441117, International IEEE/EMBS Conference on Neural Engineering, NER, vol. 2021-May, IEEE, pp. 605-608, 10th International IEEE/EMBS Conference on Neural Engineering, NER 2021, Virtual, Online, Italy, 4/05/21. https://doi.org/10.1109/NER49283.2021.9441117

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abstract = "Managing the urinary bladder after spinal cord injury is of primary importance because neurogenic dysfunction leads to life-threatening complications. Sacral Anterior Root Stimulators that control the bladder have been available for many years, however, these devices cannot sense the fullness of the bladder or detect the onset of reflex voiding. In order to address this fundamental limitation, this paper explores the possibility of recording the neural signals that encode bladder fullness from the sacral roots in sheep using extra-neural books. Stimulation of and recording from six roots (S1, S2 and S3 bilaterally) shows that efferent and afferent pathways seem to be co-located within roots, but also that simultaneous recording from multiple roots may be useful to enhance overall signal quality. ",

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AB - Managing the urinary bladder after spinal cord injury is of primary importance because neurogenic dysfunction leads to life-threatening complications. Sacral Anterior Root Stimulators that control the bladder have been available for many years, however, these devices cannot sense the fullness of the bladder or detect the onset of reflex voiding. In order to address this fundamental limitation, this paper explores the possibility of recording the neural signals that encode bladder fullness from the sacral roots in sheep using extra-neural books. Stimulation of and recording from six roots (S1, S2 and S3 bilaterally) shows that efferent and afferent pathways seem to be co-located within roots, but also that simultaneous recording from multiple roots may be useful to enhance overall signal quality.

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Urinary bladder innervation within the sacral roots of a sheep

Abstract

Publication series

Conference

Bibliographical note

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Detecting Bladder Volume and pressure from Sacral Nerve Signals: the Key to Future Artificial Control

Cite this

Urinary bladder innervation within the sacral roots of a sheep

Abstract

Publication series

Conference

Bibliographical note

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Projects

Detecting Bladder Volume and pressure from Sacral Nerve Signals: the Key to Future Artificial Control

Cite this