Updating the Psoriatic Arthritis (PsA) core domain set: A report from the PsA workshop at OMERACT 2016

Ana-Maria Orbai, Maarten de Wit, Philip J Mease, Kristina Callis Duffin, Musaab Elmamoun, William Tillett, Willemina Campbell, Oliver FitzGerald, Dafna D Gladman, Niti Goel, Laure Gossec, Pil Hoejgaard, Ying Ying Leung, Chris Lindsay, Vibeke Strand, Désirée M van der Heijde, Bev Shea, Robin Christensen, Laura Coates, Lihi EderNeil McHugh, Umut Kalyoncu, Ingrid Steinkoenig, Alexis Ogdie

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Abstract

OBJECTIVE: To include the patient perspective in accordance with the Outcome Measures in Rheumatology (OMERACT) Filter 2.0 in the updated Psoriatic Arthritis (PsA) Core Domain Set for randomized controlled trials (RCT) and longitudinal observational studies (LOS).

METHODS: At OMERACT 2016, research conducted to update the PsA Core Domain Set was presented and discussed in breakout groups. The updated PsA Core Domain Set was voted on and endorsed by OMERACT participants.

RESULTS: We conducted a systematic literature review of domains measured in PsA RCT and LOS, and identified 24 domains. We conducted 24 focus groups with 130 patients from 7 countries representing 5 continents to identify patient domains. We achieved consensus through 2 rounds of separate surveys with 50 patients and 75 physicians, and a nominal group technique meeting with 12 patients and 12 physicians. We conducted a workshop and breakout groups at OMERACT 2016 in which findings were presented and discussed. The updated PsA Core Domain Set endorsed with 90% agreement by OMERACT 2016 participants included musculoskeletal disease activity, skin disease activity, fatigue, pain, patient's global assessment, physical function, health-related quality of life, and systemic inflammation, which were recommended for all RCT and LOS. These were important, but not required in all RCT and LOS: economic cost, emotional well-being, participation, and structural damage. Independence, sleep, stiffness, and treatment burden were on the research agenda.

CONCLUSION: The updated PsA Core Domain Set was endorsed at OMERACT 2016. Next steps for the PsA working group include evaluation of PsA outcome measures and development of a PsA Core Outcome Measurement Set.

Original languageEnglish
Article number160904
Pages (from-to)1522-1528
JournalThe Journal of Rheumatology
Volume44
Issue number10
Early online date15 Feb 2017
DOIs
Publication statusPublished - 1 Oct 2017

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  • Projects

    Outcome Measures for Randomised Controlled Trials in Psoriatic Arthritis

    Tillett, W.

    1/09/163/07/20

    Project: Central government, health and local authorities

    Cite this

    Orbai, A-M., de Wit, M., Mease, P. J., Callis Duffin, K., Elmamoun, M., Tillett, W., Campbell, W., FitzGerald, O., Gladman, D. D., Goel, N., Gossec, L., Hoejgaard, P., Leung, Y. Y., Lindsay, C., Strand, V., van der Heijde, D. M., Shea, B., Christensen, R., Coates, L., ... Ogdie, A. (2017). Updating the Psoriatic Arthritis (PsA) core domain set: A report from the PsA workshop at OMERACT 2016. The Journal of Rheumatology, 44(10), 1522-1528. [160904]. https://doi.org/10.3899/jrheum.160904