Uniform acquisition modelling across PET imaging systems: Unified scatter modelling

P. J. Markiewicz, M. J. Ehrhardt, David Atkinson, S. R. Arridge, B. F. Hutton, S. Ourselin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

PET imaging is an important tool commonly used for studying disease by research consortia which implement multi-centre studies to improve the statistical power of findings. The UK government launched the Dementias Platform UK to facilitate one of the world's largest dementia population study involving national centres equipped with state-of-the-art PET/MR scanners from two major vendors. However, the difference in PET detector technology between the two scanners involved makes the standardisation of data acquisition and image reconstruction necessary. We propose a new approach to PET acquisition system modelling across different PET systems and technologies, focusing in particular on unified scatter estimation across TOF (time-of-flight) and non-TOF PET systems. The proposed scatter modelling is fully 3D and voxel based, as opposed to the popular line-of-response driven methods. This means that for each emitting voxel an independent 3D scatter estimate is found, inherently preserving the necessary information for TOF calculations as well as accounting for the large axial field of view. With adequate sampling of the input images, the non-TOF scatter estimate is identical to the summed TOF estimates across TOF bins, without an additional computational cost used for the TOF estimation. The model is implemented using the latest NVIDA GPU CUDA platform, allowing finer sampling of image space which is more essential for accurate TOF modelling. The high accuracy of the proposed scatter model is validated using Monte Carlo simulations. The model is deployed in our stand-alone image reconstruction pipeline for the Biograph mMR scanner, demonstrating accurate 3D scatter estimates resulting in uniform reconstruction for a high statistics phantom scan.

LanguageEnglish
Title of host publication2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016
PublisherIEEE
Volume2017-January
ISBN (Electronic)9781509016426
DOIs
StatusPublished - 16 Oct 2017
Event2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016 - Strasbourg, France
Duration: 29 Oct 20166 Nov 2016

Conference

Conference2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016
CountryFrance
CityStrasbourg
Period29/10/166/11/16

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Instrumentation
  • Nuclear and High Energy Physics
  • Electronic, Optical and Magnetic Materials

Cite this

Markiewicz, P. J., Ehrhardt, M. J., Atkinson, D., Arridge, S. R., Hutton, B. F., & Ourselin, S. (2017). Uniform acquisition modelling across PET imaging systems: Unified scatter modelling. In 2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016 (Vol. 2017-January). [8069584] IEEE. https://doi.org/10.1109/NSSMIC.2016.08069584

Uniform acquisition modelling across PET imaging systems : Unified scatter modelling. / Markiewicz, P. J.; Ehrhardt, M. J.; Atkinson, David; Arridge, S. R.; Hutton, B. F.; Ourselin, S.

2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016. Vol. 2017-January IEEE, 2017. 8069584.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Markiewicz, PJ, Ehrhardt, MJ, Atkinson, D, Arridge, SR, Hutton, BF & Ourselin, S 2017, Uniform acquisition modelling across PET imaging systems: Unified scatter modelling. in 2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016. vol. 2017-January, 8069584, IEEE, 2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016, Strasbourg, France, 29/10/16. https://doi.org/10.1109/NSSMIC.2016.08069584
Markiewicz PJ, Ehrhardt MJ, Atkinson D, Arridge SR, Hutton BF, Ourselin S. Uniform acquisition modelling across PET imaging systems: Unified scatter modelling. In 2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016. Vol. 2017-January. IEEE. 2017. 8069584 https://doi.org/10.1109/NSSMIC.2016.08069584
Markiewicz, P. J. ; Ehrhardt, M. J. ; Atkinson, David ; Arridge, S. R. ; Hutton, B. F. ; Ourselin, S. / Uniform acquisition modelling across PET imaging systems : Unified scatter modelling. 2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016. Vol. 2017-January IEEE, 2017.
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