Projects per year
Abstract
alpha-Methylacyl-CoA racemase (AMACR;double dagger P504S) catalysed exchange of straight-chain fatty acyl-CoA alpha-protons. One alpha-proton was removed in each catalytic cycle, with the pro-S proton preferred. This reaction was most efficient for straight-chain substrates with longer side-chains. 2-Methyldecanoyl-CoA underwent alpha-proton exchange 3x more efficiently (as judged by K-cat/K-m) than decanoyl-CoA.
Original language | English |
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Pages (from-to) | 3348-3350 |
Number of pages | 3 |
Journal | Chemical Communications |
Volume | 46 |
Issue number | 19 |
Early online date | 29 Mar 2010 |
DOIs | |
Publication status | Published - 21 May 2010 |
Fingerprint
Dive into the research topics of 'Unexpected stereoselective exchange of straight-chain fatty acyl-CoA α-protons by human α-methylacyl-CoA racemase 1A (P504S)'. Together they form a unique fingerprint.Projects
- 1 Finished
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Isoforms as a Novel Target for Prostatic Cancer
Lloyd, M. (PI) & Threadgill, M. (CoI)
1/05/06 → 30/04/09
Project: UK charity
Equipment
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Avance III 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer (9West)
Material and Chemical Characterisation (MC2)Facility/equipment: Equipment
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MC2- Nuclear Magnetic Resonance (NMR)
Material and Chemical Characterisation (MC2)Facility/equipment: Technology type