Abstract
The use of silyl nitronates is reported for the isothiourea-catalyzed synthesis of γ-nitro-substituted silyl esters containing up to two contiguous stereocenters in good yields with excellent enantioselectivities (up to 93% yield and 99:1 er). The serendipitously discovered formation of silyl ester products in this reaction demonstrates a novel platform for catalyst turnover in α,β-unsaturated acyl ammonium catalysis.
Original language | English |
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Pages (from-to) | 335-339 |
Number of pages | 5 |
Journal | Organic Letters |
Volume | 22 |
Issue number | 1 |
Early online date | 23 Dec 2019 |
DOIs | |
Publication status | Published - 3 Jan 2020 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry