Tyramine antagonizes proctolin-induced contraction of the isolated foregut of the locust Schistocerca gregaria by an interaction with octopamine2 receptors

S E Banner; S J Wood; R H Osborne; K J Cattell

doi:10.1016/0742-8413(90)90110-u

Tyramine antagonizes proctolin-induced contraction of the isolated foregut of the locust Schistocerca gregaria by an interaction with octopamine2 receptors

S E Banner, S J Wood, R H Osborne, K J Cattell

Beecham Pharmaceuticals

Research output: Contribution to journal › Article › peer-review

Abstract

1. Octopamine (OA) (10(-7)-10(-5) M) relaxed isolated foreguts. Tyramine mimicked the effects of OA but was 64x less potent. 2. Proctolin (10(-8) M to 10(-6) M) induced contraction of isolated foreguts was antagonised non competitively by tyramine. 3. Mianserin (10(-6) M) was a non competitive antagonist of relaxation caused by tyramine but was without effect on proctolin induced contraction. 4. Caffeine (1 microM and 2 microM) caused non competitive inhibition of proctolin-induced tissue contraction. 5. It is concluded that tyramine antagonises proctolin-induced contraction of the foregut by activating an adenylate cyclase-linked OA2 receptor.

Original language	English
Pages (from-to)	233-6
Number of pages	4
Journal	Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology
Volume	95
Issue number	2
DOIs	https://doi.org/10.1016/0742-8413(90)90110-u
Publication status	Published - 1990

Keywords

Animals
Caffeine/pharmacology
Digestive System/drug effects
Digestive System Physiological Phenomena
Dose-Response Relationship, Drug
Female
Grasshoppers/physiology
Male
Mianserin/pharmacology
Muscle Contraction/drug effects
Muscle, Smooth/drug effects
Neuropeptides
Octopamine/pharmacology
Oligopeptides/antagonists & inhibitors
Receptors, Adrenergic/metabolism
Receptors, Biogenic Amine
Tyramine/pharmacology

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10.1016/0742-8413(90)90110-u

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Tyramine antagonizes proctolin-induced contraction of the isolated foregut of the locust Schistocerca gregaria by an interaction with octopamine2 receptors. / Banner, S E; Wood, S J; Osborne, R H et al.
In: Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology, Vol. 95, No. 2, 1990, p. 233-6.

Research output: Contribution to journal › Article › peer-review

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title = "Tyramine antagonizes proctolin-induced contraction of the isolated foregut of the locust Schistocerca gregaria by an interaction with octopamine2 receptors",

abstract = "1. Octopamine (OA) (10(-7)-10(-5) M) relaxed isolated foreguts. Tyramine mimicked the effects of OA but was 64x less potent. 2. Proctolin (10(-8) M to 10(-6) M) induced contraction of isolated foreguts was antagonised non competitively by tyramine. 3. Mianserin (10(-6) M) was a non competitive antagonist of relaxation caused by tyramine but was without effect on proctolin induced contraction. 4. Caffeine (1 microM and 2 microM) caused non competitive inhibition of proctolin-induced tissue contraction. 5. It is concluded that tyramine antagonises proctolin-induced contraction of the foregut by activating an adenylate cyclase-linked OA2 receptor.",

keywords = "Animals, Caffeine/pharmacology, Digestive System/drug effects, Digestive System Physiological Phenomena, Dose-Response Relationship, Drug, Female, Grasshoppers/physiology, Male, Mianserin/pharmacology, Muscle Contraction/drug effects, Muscle, Smooth/drug effects, Neuropeptides, Octopamine/pharmacology, Oligopeptides/antagonists & inhibitors, Receptors, Adrenergic/metabolism, Receptors, Biogenic Amine, Tyramine/pharmacology",

author = "Banner, {S E} and Wood, {S J} and Osborne, {R H} and Cattell, {K J}",

year = "1990",

doi = "10.1016/0742-8413(90)90110-u",

language = "English",

volume = "95",

pages = "233--6",

journal = "Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology",

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TY - JOUR

T1 - Tyramine antagonizes proctolin-induced contraction of the isolated foregut of the locust Schistocerca gregaria by an interaction with octopamine2 receptors

AU - Banner, S E

AU - Wood, S J

AU - Osborne, R H

AU - Cattell, K J

PY - 1990

Y1 - 1990

N2 - 1. Octopamine (OA) (10(-7)-10(-5) M) relaxed isolated foreguts. Tyramine mimicked the effects of OA but was 64x less potent. 2. Proctolin (10(-8) M to 10(-6) M) induced contraction of isolated foreguts was antagonised non competitively by tyramine. 3. Mianserin (10(-6) M) was a non competitive antagonist of relaxation caused by tyramine but was without effect on proctolin induced contraction. 4. Caffeine (1 microM and 2 microM) caused non competitive inhibition of proctolin-induced tissue contraction. 5. It is concluded that tyramine antagonises proctolin-induced contraction of the foregut by activating an adenylate cyclase-linked OA2 receptor.

AB - 1. Octopamine (OA) (10(-7)-10(-5) M) relaxed isolated foreguts. Tyramine mimicked the effects of OA but was 64x less potent. 2. Proctolin (10(-8) M to 10(-6) M) induced contraction of isolated foreguts was antagonised non competitively by tyramine. 3. Mianserin (10(-6) M) was a non competitive antagonist of relaxation caused by tyramine but was without effect on proctolin induced contraction. 4. Caffeine (1 microM and 2 microM) caused non competitive inhibition of proctolin-induced tissue contraction. 5. It is concluded that tyramine antagonises proctolin-induced contraction of the foregut by activating an adenylate cyclase-linked OA2 receptor.

KW - Animals

KW - Caffeine/pharmacology

KW - Digestive System/drug effects

KW - Digestive System Physiological Phenomena

KW - Dose-Response Relationship, Drug

KW - Female

KW - Grasshoppers/physiology

KW - Male

KW - Mianserin/pharmacology

KW - Muscle Contraction/drug effects

KW - Muscle, Smooth/drug effects

KW - Neuropeptides

KW - Octopamine/pharmacology

KW - Oligopeptides/antagonists & inhibitors

KW - Receptors, Adrenergic/metabolism

KW - Receptors, Biogenic Amine

KW - Tyramine/pharmacology

U2 - 10.1016/0742-8413(90)90110-u

DO - 10.1016/0742-8413(90)90110-u

M3 - Article

C2 - 1977552

SN - 0742-8413

VL - 95

SP - 233

EP - 236

JO - Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology

JF - Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology

IS - 2

ER -

Tyramine antagonizes proctolin-induced contraction of the isolated foregut of the locust Schistocerca gregaria by an interaction with octopamine2 receptors

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Keywords

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