Two new cyclic tetrapeptides from deep-sea bacterium bacillus amyloliquefaciens GAS 00152

C.-H. Gao, Y.-N. Chen, L.-X. Pan, F. Lei, B. Long, L.-Q. Hu, R.-C. Zhang, K. Ke, R.-M. Huang

Research output: Contribution to journalArticlepeer-review

19 Citations (SciVal)


Marine microorganisms continue to be a productive focus for much of marine natural products investigation.1, 2, 3 These organisms flourishing in diverse marine environments, have produced a wide variety of structurally unique and biologically active secondary metabolites many of which have attracted considerable attention.1, 4 In the last decades, the number of reported secondary metabolites from marine bacteria has steadily increased.2 Medium ring-sized peptides containing the amino acids leucine, isoleucine, phenylalanine, valine and proline have been reported from diverse marine sources, including microorganisms.5, 6 The genus Bacillus has produced biologically active compounds.7, 8 In our search for bioactive natural products from the bacterium B. amyloliquefaciens collected from South China Sea deep-sea sediment, the culture broth contained two new cyclic tetrapeptides, cyclo-(Leu-Pro-Ile-Pro) (1) and cyclo-(Tyr-Pro-Phe-Gly) (2) (Figure 1).

Original languageEnglish
Pages (from-to)541-543
Number of pages3
JournalJournal of Antibiotics
Publication statusPublished - Jul 2014


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