Two-component system that controls bacterial membrane synthesis

Andrew Preston (Inventor), M A Apicella (Inventor)

Research output: Patent

Abstract

The present invention discloses a mutant Neisseria having extensive membrane blebbing, both an indicium and a cause of virulence in the gonococcus and meningococcus. Methods are disclosed for making and characterizing the mutant, bmrRS. Methods are disclosed for isolating bmrRS membranes for use as a vaccine. Methods are also disclosed for the use of the mutant for determining the virulence of clinical samples of N. gonorrhoeae and N. meningitidis. Methods are also disclosed for the screening of antibiotics targeted to virulent Neisseria.
Original languageEnglish
Patent numberUS 7,189,554 B2
Publication statusPublished - 13 Mar 2007

Fingerprint Dive into the research topics of 'Two-component system that controls bacterial membrane synthesis'. Together they form a unique fingerprint.

  • Cite this

    Preston, A., & Apicella, M. A. (2007). Two-component system that controls bacterial membrane synthesis. (Patent No. US 7,189,554 B2).