Turning one cell type into another

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

The nature of cells in early embryos may be respecified simply by exposure to inducing factors. In later stage embryos, determined cell populations do not respond to inducing factors but may be respecified by other stimuli, especially the introduction of specific transcription factors. Fully differentiated cell types are hard to respecify by any method, but some degree of success can be achieved using selected combinations of transcription factors, and this may have clinical significance in the future.

Original languageEnglish
Title of host publicationCurrent Topics in Developmental Biology
EditorsPaul M. Wassarman
PublisherElsevier
Pages339-358
Volume117
ISBN (Print)78-0-12-801382-3
DOIs
Publication statusE-pub ahead of print - 7 Jan 2016

Keywords

  • Commitment
  • Determination
  • Differentiation
  • Inducing factor
  • Metaplasia

Fingerprint Dive into the research topics of 'Turning one cell type into another'. Together they form a unique fingerprint.

  • Cite this

    Slack, J. M. W. (2016). Turning one cell type into another. In P. M. Wassarman (Ed.), Current Topics in Developmental Biology (Vol. 117, pp. 339-358). Elsevier. https://doi.org/10.1016/bs.ctdb.2015.11.017