Tuning morphology in active pharmaceutical ingredients: Controlling the crystal habit of lovastatin through solvent choice and non-size-matched polymer additives

Lauren E. Hatcher, Wei Li, Pollyanna Payne, Brahim Benyahia, Chris D. Rielly, Chick C. Wilson

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Additive crystallization routes to control the crystal habit of the active pharmaceutical ingredient (API) lovastatin are presented, at small scale up to 25 mL. Lovastatin is an archetypical example of an API that forms needle-like crystals via solution-based recrystallization, causing issues for downstream pharmaceutical processing stages. In this work, the size and shape of lovastatin needles are shown to be subtly influenced by the crystallization solvent, concentration, and crystallization procedure, with moderately hygroscopic ethyl acetate solvent producing needles with improved aspect ratios in comparison to the acetone/water mixtures primarily used for industrial recrystallization. Further, the inclusion of soluble, non-size-matched polymer additives, at very low concentrations (0.5 wt %/wt), into the solution has a pronounced impact on the crystal habit. While the inclusion of the hydrophilic polymer poly(ethylene glycol) promotes the formation of even longer, thinner needles than those formed by nonadditive routes, the use of hydrophobic poly(propylene glycol) improves the habit from needles toward plate-like crystals. The product materials are analyzed by a combination of microscopy, thermal analysis, and diffraction-based techniques, with the latter enabling rationalization of the habit control via identification of the prominent crystal faces and growth directions with respect to the underlying crystal structure.

Original languageEnglish
Pages (from-to)5854-5862
Number of pages9
JournalCrystal Growth and Design
Volume20
Issue number9
Early online date4 Aug 2020
DOIs
Publication statusPublished - 2 Sep 2020

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

Fingerprint Dive into the research topics of 'Tuning morphology in active pharmaceutical ingredients: Controlling the crystal habit of lovastatin through solvent choice and non-size-matched polymer additives'. Together they form a unique fingerprint.

Cite this