Tumor microenvironment-oriented MOFs for chemodynamic therapy

Xiaojiao Di; Zhichao Pei; Yuxin Pei; Tony D. James

doi:10.1016/j.ccr.2023.215098

Tumor microenvironment-oriented MOFs for chemodynamic therapy

Xiaojiao Di, Zhichao Pei, Yuxin Pei, Tony D. James

Department of Chemistry

Research output: Contribution to journal › Review article › peer-review

54 Citations (SciVal)

Abstract

Non-invasive tumor therapy via in situ ROS generation is emerging as an appealing treatment modality with the potential for deep-seated tumors without side effects on healthy tissue. Chemodynamic therapy (CDT) based on Fenton/Fenton-like reactions is a non-invasive cancer treatment, which converts hydrogen peroxide (H₂O₂) found locally into lethal hydroxyl radicals ([rad]OH) through the exploitation of transition metal ions as catalysts in an acidic tumor microenvironment (TME) suitable for effective oncotherapy. Metal-organic frameworks (MOFs) exhibit great promise for CDT on account of their unique properties. Among them, the stimuli-responsive nature and the porosity of MOFs make them ideal for TME-targeted cargo delivery. In addition, the ability to select appropriate metal ions and organic ligands makes it possible to prepare MOFs with intrinsic antitumor activity. This review primarily summarizes the latest progress in the application of tumor microenvironment-oriented MOFs for CDT, including MOFs without or with intrinsic chemodynamic activity. Furthermore, the remaining challenges and suggestions for future applications of MOFs for CDT are also presented.

Original language	English
Article number	215098
Journal	Coordination Chemistry Reviews
Volume	484
Early online date	14 Mar 2023
DOIs	https://doi.org/10.1016/j.ccr.2023.215098
Publication status	Published - 1 Jun 2023

Bibliographical note

Funding Information:
This project was financially supported by the National Natural Science Foundation of China (21772157 and 21877088) and the Project of Science and Technology of Social Development in Shaanxi Province (2021SF-120). T.D.J. wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support (2020ZD01). We would like to thank the Royal Society for support as part of International Exchanges 2021 Cost Share (NSFC)(IEC\NSFC\211304).

Data Availability
No data was used for the research described in this article

Funding

This project was financially supported by the National Natural Science Foundation of China (21772157 and 21877088) and the Project of Science and Technology of Social Development in Shaanxi Province (2021SF-120). T.D.J. wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support (2020ZD01). We would like to thank the Royal Society for support as part of International Exchanges 2021 Cost Share (NSFC)(IEC\NSFC\211304).

Keywords

Chemodynamic therapy
Fenton/Fenton-like reactions
Intrinsic chemodynamic activity
Metal–organic frameworks
Tumor microenvironment

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.ccr.2023.215098Licence: CC BY

Cite this

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title = "Tumor microenvironment-oriented MOFs for chemodynamic therapy",

abstract = "Non-invasive tumor therapy via in situ ROS generation is emerging as an appealing treatment modality with the potential for deep-seated tumors without side effects on healthy tissue. Chemodynamic therapy (CDT) based on Fenton/Fenton-like reactions is a non-invasive cancer treatment, which converts hydrogen peroxide (H2O2) found locally into lethal hydroxyl radicals ([rad]OH) through the exploitation of transition metal ions as catalysts in an acidic tumor microenvironment (TME) suitable for effective oncotherapy. Metal-organic frameworks (MOFs) exhibit great promise for CDT on account of their unique properties. Among them, the stimuli-responsive nature and the porosity of MOFs make them ideal for TME-targeted cargo delivery. In addition, the ability to select appropriate metal ions and organic ligands makes it possible to prepare MOFs with intrinsic antitumor activity. This review primarily summarizes the latest progress in the application of tumor microenvironment-oriented MOFs for CDT, including MOFs without or with intrinsic chemodynamic activity. Furthermore, the remaining challenges and suggestions for future applications of MOFs for CDT are also presented.",

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author = "Xiaojiao Di and Zhichao Pei and Yuxin Pei and James, {Tony D.}",

note = "Funding Information: This project was financially supported by the National Natural Science Foundation of China (21772157 and 21877088) and the Project of Science and Technology of Social Development in Shaanxi Province (2021SF-120). T.D.J. wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support (2020ZD01). We would like to thank the Royal Society for support as part of International Exchanges 2021 Cost Share (NSFC)(IEC\NSFC\211304). Data Availability No data was used for the research described in this article ",

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N1 - Funding Information: This project was financially supported by the National Natural Science Foundation of China (21772157 and 21877088) and the Project of Science and Technology of Social Development in Shaanxi Province (2021SF-120). T.D.J. wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support (2020ZD01). We would like to thank the Royal Society for support as part of International Exchanges 2021 Cost Share (NSFC)(IEC\NSFC\211304). Data Availability No data was used for the research described in this article

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N2 - Non-invasive tumor therapy via in situ ROS generation is emerging as an appealing treatment modality with the potential for deep-seated tumors without side effects on healthy tissue. Chemodynamic therapy (CDT) based on Fenton/Fenton-like reactions is a non-invasive cancer treatment, which converts hydrogen peroxide (H2O2) found locally into lethal hydroxyl radicals ([rad]OH) through the exploitation of transition metal ions as catalysts in an acidic tumor microenvironment (TME) suitable for effective oncotherapy. Metal-organic frameworks (MOFs) exhibit great promise for CDT on account of their unique properties. Among them, the stimuli-responsive nature and the porosity of MOFs make them ideal for TME-targeted cargo delivery. In addition, the ability to select appropriate metal ions and organic ligands makes it possible to prepare MOFs with intrinsic antitumor activity. This review primarily summarizes the latest progress in the application of tumor microenvironment-oriented MOFs for CDT, including MOFs without or with intrinsic chemodynamic activity. Furthermore, the remaining challenges and suggestions for future applications of MOFs for CDT are also presented.

AB - Non-invasive tumor therapy via in situ ROS generation is emerging as an appealing treatment modality with the potential for deep-seated tumors without side effects on healthy tissue. Chemodynamic therapy (CDT) based on Fenton/Fenton-like reactions is a non-invasive cancer treatment, which converts hydrogen peroxide (H2O2) found locally into lethal hydroxyl radicals ([rad]OH) through the exploitation of transition metal ions as catalysts in an acidic tumor microenvironment (TME) suitable for effective oncotherapy. Metal-organic frameworks (MOFs) exhibit great promise for CDT on account of their unique properties. Among them, the stimuli-responsive nature and the porosity of MOFs make them ideal for TME-targeted cargo delivery. In addition, the ability to select appropriate metal ions and organic ligands makes it possible to prepare MOFs with intrinsic antitumor activity. This review primarily summarizes the latest progress in the application of tumor microenvironment-oriented MOFs for CDT, including MOFs without or with intrinsic chemodynamic activity. Furthermore, the remaining challenges and suggestions for future applications of MOFs for CDT are also presented.

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Tumor microenvironment-oriented MOFs for chemodynamic therapy

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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