TY - JOUR
T1 - Tumor microenvironment-oriented MOFs for chemodynamic therapy
AU - Di, Xiaojiao
AU - Pei, Zhichao
AU - Pei, Yuxin
AU - James, Tony D.
N1 - Funding Information:
This project was financially supported by the National Natural Science Foundation of China (21772157 and 21877088) and the Project of Science and Technology of Social Development in Shaanxi Province (2021SF-120). T.D.J. wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support (2020ZD01). We would like to thank the Royal Society for support as part of International Exchanges 2021 Cost Share (NSFC)(IEC\NSFC\211304).
Data Availability
No data was used for the research described in this article
PY - 2023/6/1
Y1 - 2023/6/1
N2 - Non-invasive tumor therapy via in situ ROS generation is emerging as an appealing treatment modality with the potential for deep-seated tumors without side effects on healthy tissue. Chemodynamic therapy (CDT) based on Fenton/Fenton-like reactions is a non-invasive cancer treatment, which converts hydrogen peroxide (H2O2) found locally into lethal hydroxyl radicals ([rad]OH) through the exploitation of transition metal ions as catalysts in an acidic tumor microenvironment (TME) suitable for effective oncotherapy. Metal-organic frameworks (MOFs) exhibit great promise for CDT on account of their unique properties. Among them, the stimuli-responsive nature and the porosity of MOFs make them ideal for TME-targeted cargo delivery. In addition, the ability to select appropriate metal ions and organic ligands makes it possible to prepare MOFs with intrinsic antitumor activity. This review primarily summarizes the latest progress in the application of tumor microenvironment-oriented MOFs for CDT, including MOFs without or with intrinsic chemodynamic activity. Furthermore, the remaining challenges and suggestions for future applications of MOFs for CDT are also presented.
AB - Non-invasive tumor therapy via in situ ROS generation is emerging as an appealing treatment modality with the potential for deep-seated tumors without side effects on healthy tissue. Chemodynamic therapy (CDT) based on Fenton/Fenton-like reactions is a non-invasive cancer treatment, which converts hydrogen peroxide (H2O2) found locally into lethal hydroxyl radicals ([rad]OH) through the exploitation of transition metal ions as catalysts in an acidic tumor microenvironment (TME) suitable for effective oncotherapy. Metal-organic frameworks (MOFs) exhibit great promise for CDT on account of their unique properties. Among them, the stimuli-responsive nature and the porosity of MOFs make them ideal for TME-targeted cargo delivery. In addition, the ability to select appropriate metal ions and organic ligands makes it possible to prepare MOFs with intrinsic antitumor activity. This review primarily summarizes the latest progress in the application of tumor microenvironment-oriented MOFs for CDT, including MOFs without or with intrinsic chemodynamic activity. Furthermore, the remaining challenges and suggestions for future applications of MOFs for CDT are also presented.
KW - Chemodynamic therapy
KW - Fenton/Fenton-like reactions
KW - Intrinsic chemodynamic activity
KW - Metal–organic frameworks
KW - Tumor microenvironment
UR - http://www.scopus.com/inward/record.url?scp=85150188670&partnerID=8YFLogxK
U2 - 10.1016/j.ccr.2023.215098
DO - 10.1016/j.ccr.2023.215098
M3 - Review article
AN - SCOPUS:85150188670
SN - 0010-8545
VL - 484
JO - Coordination Chemistry Reviews
JF - Coordination Chemistry Reviews
M1 - 215098
ER -
