Trends in fluoroquinolone resistance in Campylobacter

Emma L. Sproston, Helen M.L. Wimalarathna, Samuel K. Sheppard

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Members of the genus Campylobacter remain a leading cause of bacterial gastroenteritis worldwide. Infection is usually self-limiting but in severe cases may require antibiotic treatment. In a recent statement by the World Health Organization (WHO) Campylobacter was named as one of the 12 bacteria that pose the greatest threat to human health because they are resistant to antibiotics. In this mini review we describe recent trends in fluoroquinolone (FQ) (particularly ciprofloxacin) resistance in strains of members of the genus Campylobacter isolated from livestock and clinical samples from several countries. Using evidence from phenotyping surveys and putative resistance prediction from DNA sequence data, we discuss the acquisition and spread of FQ resistance and the role of horizontal gene transfer and describe trends in FQ-resistance in samples from livestock and clinical cases. This review emphasises that FQ resistance remains common among isolates of members of the genus Campylobacter from various sources.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalMicrobial Genomics
Volume4
Issue number8
Early online date19 Jul 2018
DOIs
Publication statusPublished - 1 Aug 2018

Keywords

  • Campylobacter
  • ciprofloxacin
  • fluoroquinolones
  • resistance

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Trends in fluoroquinolone resistance in Campylobacter. / Sproston, Emma L.; Wimalarathna, Helen M.L.; Sheppard, Samuel K.

In: Microbial Genomics, Vol. 4, No. 8, 01.08.2018, p. 1-8.

Research output: Contribution to journalArticle

Sproston, Emma L. ; Wimalarathna, Helen M.L. ; Sheppard, Samuel K. / Trends in fluoroquinolone resistance in Campylobacter. In: Microbial Genomics. 2018 ; Vol. 4, No. 8. pp. 1-8.
@article{63f5214defec40af93d6b78f95e02f6a,
title = "Trends in fluoroquinolone resistance in Campylobacter",
abstract = "Members of the genus Campylobacter remain a leading cause of bacterial gastroenteritis worldwide. Infection is usually self-limiting but in severe cases may require antibiotic treatment. In a recent statement by the World Health Organization (WHO) Campylobacter was named as one of the 12 bacteria that pose the greatest threat to human health because they are resistant to antibiotics. In this mini review we describe recent trends in fluoroquinolone (FQ) (particularly ciprofloxacin) resistance in strains of members of the genus Campylobacter isolated from livestock and clinical samples from several countries. Using evidence from phenotyping surveys and putative resistance prediction from DNA sequence data, we discuss the acquisition and spread of FQ resistance and the role of horizontal gene transfer and describe trends in FQ-resistance in samples from livestock and clinical cases. This review emphasises that FQ resistance remains common among isolates of members of the genus Campylobacter from various sources.",
keywords = "Campylobacter, ciprofloxacin, fluoroquinolones, resistance",
author = "Sproston, {Emma L.} and Wimalarathna, {Helen M.L.} and Sheppard, {Samuel K.}",
year = "2018",
month = "8",
day = "1",
doi = "10.1099/mgen.0.000198",
language = "English",
volume = "4",
pages = "1--8",
journal = "Microbial Genomics",
issn = "2057-5858",
publisher = "Microbiology Society",
number = "8",

}

TY - JOUR

T1 - Trends in fluoroquinolone resistance in Campylobacter

AU - Sproston, Emma L.

AU - Wimalarathna, Helen M.L.

AU - Sheppard, Samuel K.

PY - 2018/8/1

Y1 - 2018/8/1

N2 - Members of the genus Campylobacter remain a leading cause of bacterial gastroenteritis worldwide. Infection is usually self-limiting but in severe cases may require antibiotic treatment. In a recent statement by the World Health Organization (WHO) Campylobacter was named as one of the 12 bacteria that pose the greatest threat to human health because they are resistant to antibiotics. In this mini review we describe recent trends in fluoroquinolone (FQ) (particularly ciprofloxacin) resistance in strains of members of the genus Campylobacter isolated from livestock and clinical samples from several countries. Using evidence from phenotyping surveys and putative resistance prediction from DNA sequence data, we discuss the acquisition and spread of FQ resistance and the role of horizontal gene transfer and describe trends in FQ-resistance in samples from livestock and clinical cases. This review emphasises that FQ resistance remains common among isolates of members of the genus Campylobacter from various sources.

AB - Members of the genus Campylobacter remain a leading cause of bacterial gastroenteritis worldwide. Infection is usually self-limiting but in severe cases may require antibiotic treatment. In a recent statement by the World Health Organization (WHO) Campylobacter was named as one of the 12 bacteria that pose the greatest threat to human health because they are resistant to antibiotics. In this mini review we describe recent trends in fluoroquinolone (FQ) (particularly ciprofloxacin) resistance in strains of members of the genus Campylobacter isolated from livestock and clinical samples from several countries. Using evidence from phenotyping surveys and putative resistance prediction from DNA sequence data, we discuss the acquisition and spread of FQ resistance and the role of horizontal gene transfer and describe trends in FQ-resistance in samples from livestock and clinical cases. This review emphasises that FQ resistance remains common among isolates of members of the genus Campylobacter from various sources.

KW - Campylobacter

KW - ciprofloxacin

KW - fluoroquinolones

KW - resistance

UR - http://www.scopus.com/inward/record.url?scp=85054897494&partnerID=8YFLogxK

U2 - 10.1099/mgen.0.000198

DO - 10.1099/mgen.0.000198

M3 - Article

VL - 4

SP - 1

EP - 8

JO - Microbial Genomics

JF - Microbial Genomics

SN - 2057-5858

IS - 8

ER -