Transition metal catalysed reactions of alcohols using borrowing hydrogen methodology

Tracy D Nixon, Michael K Whittlesey, Jonathan M J Williams

Research output: Contribution to journalArticle

480 Citations (Scopus)

Abstract

The reactivity of alcohols can be enhanced by the temporary removal of hydrogen using a transition metal catalyst to generate an intermediate aldehyde or ketone. The so-formed carbonyl compound has a greater reactivity towards nucleophilic addition accommodating the in situ formation of imines or alkenes. The return of hydrogen from the catalyst leads to the formation of new C-N and C-C bonds, often with water as the only reaction by-product.
Original languageEnglish
Pages (from-to)753-762
Number of pages10
JournalDalton Transactions
Volume5
DOIs
Publication statusPublished - 2009

Keywords

  • Ketones
  • Carbonylation
  • Metal recovery
  • Hydrocarbons
  • Transition metals
  • Olefins
  • Organic compounds
  • Hydrogen
  • Nitrogen compounds
  • Aldehydes
  • Hydrogen bonds
  • Catalysis

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