Transgene-design: A web application for the design of mammalian transgenes

Stefanie Mühlhausen, Laurence D. Hurst

Research output: Contribution to journalArticlepeer-review

2 Citations (SciVal)
51 Downloads (Pure)

Abstract

Transgene-design is a web application to help design transgenes for use in mammalian studies. It is predicated on the recent discovery that human intronless transgenes and native retrogenes can be expressed very effectively if the GC content at exonic synonymous sites is high. In addition, as exonic splice enhancers resident in intron containing genes may have different utility in intronless genes, these can be reduced or increased in density. Input can be a native gene or a commercially 'optimised' gene. The option to leave in the first intron and to protect or avoid other motifs is also permitted.

Original languageEnglish
Pages (from-to)2626-2627
Number of pages2
JournalBioinformatics
Volume38
Issue number9
DOIs
Publication statusPublished - 1 May 2022

ASJC Scopus subject areas

  • Statistics and Probability
  • Biochemistry
  • Molecular Biology
  • Computer Science Applications
  • Computational Theory and Mathematics
  • Computational Mathematics

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