Method for carrying out transdifferentiation of non-pancreatic cells to pancreatic cells involving the provision of a pancreas specific transcription factor and an activating means such as VP16 of Herpes simplex virus to non-pancreatic cells. The methods and materials provided by the invention may be used to treat pancreatic disorders, in particular disorders caused by a loss of properly functioning pancreas such as pancreatic cancer and diabetes.
title = "Transdifferentiation of Cells and Tissues",
abstract = "Method for carrying out transdifferentiation of non-pancreatic cells to pancreatic cells involving the provision of a pancreas specific transcription factor and an activating means such as VP16 of Herpes simplex virus to non-pancreatic cells. The methods and materials provided by the invention may be used to treat pancreatic disorders, in particular disorders caused by a loss of properly functioning pancreas such as pancreatic cancer and diabetes.",
author = "Jonathan Slack and Marko Horb and David Tosh",
year = "2003",
month = "9",
day = "25",
language = "English",
type = "Patent",
note = "WO03078636 (A1); C07K14/035",
}
TY - PAT
T1 - Transdifferentiation of Cells and Tissues
AU - Slack, Jonathan
AU - Horb , Marko
AU - Tosh, David
PY - 2003/9/25
Y1 - 2003/9/25
N2 - Method for carrying out transdifferentiation of non-pancreatic cells to pancreatic cells involving the provision of a pancreas specific transcription factor and an activating means such as VP16 of Herpes simplex virus to non-pancreatic cells. The methods and materials provided by the invention may be used to treat pancreatic disorders, in particular disorders caused by a loss of properly functioning pancreas such as pancreatic cancer and diabetes.
AB - Method for carrying out transdifferentiation of non-pancreatic cells to pancreatic cells involving the provision of a pancreas specific transcription factor and an activating means such as VP16 of Herpes simplex virus to non-pancreatic cells. The methods and materials provided by the invention may be used to treat pancreatic disorders, in particular disorders caused by a loss of properly functioning pancreas such as pancreatic cancer and diabetes.