Abstract
Method for carrying out transdifferentiation of non-pancreatic cells to pancreatic cells involving the provision of a pancreas specific transcription factor and an activating means such as VP16 of Herpes simplex virus to non-pancreatic cells. The methods and materials provided by the invention may be used to treat pancreatic disorders, in particular disorders caused by a loss of properly functioning pancreas such as pancreatic cancer and diabetes.
Original language | English |
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Patent number | WO03078636 (A1) |
IPC | C07K14/005,C07K14/4702 ,C12N5/0676 |
Priority date | 18/03/02 |
Publication status | Published - 25 Sept 2003 |