Transdifferentiation in developmental biology, disease, and in therapy

S Thowfeequ, Emily-Jane Myatt, D Tosh

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Transdifferentiation (or metaplasia) refers to the conversion of one cell type to another. Because transdifferentiation normally occurs between cells that arise from the same region of the embryo, understanding the molecular and cellular events in cell type transformations may help to explain the mechanisms underlying normal development. Here we review examples of transdifferentiation in nature focusing on the possible role of cell type switching in metamorphosis and regeneration. We also examine transdifferentiation in mammals in relation to disease and the use of transdifferentiated cells in cellular therapy.
Original languageEnglish
Pages (from-to)3208-3217
Number of pages10
JournalDevelopmental Dynamics
Volume236
Issue number12
DOIs
Publication statusPublished - Dec 2007

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