Transdifferentiation and metaplasia as a paradigm for understanding development and disease

D Eberhard, D Tosh

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The ability to produce differentiated cell types at will offers one approach to cell therapy and therefore the treatment and cure of degenerative diseases such as diabetes and liver failure. Until recently it was thought that differentiated cells could only be produced from embryonic or adult stem cells. However, we now know that this is not the case, and there is a growing body of evidence to show that one differentiated cell type can convert into a completely different phenotype (transdifferentiation). Understanding the cellular and molecular basis of transdifferentiation will allow us to reprogram cells for transplantation. This approach will complement the use of embryonic and adult stem cells in the treatment of degenerative disorders. In this review, we will focus on some well-documented examples of transdifferentiation.
Original languageEnglish
Pages (from-to)33-40
Number of pages8
JournalCellular and Molecular Life Sciences (CMLS)
Volume65
Issue number1
DOIs
Publication statusPublished - Jan 2008

Fingerprint

Metaplasia
Adult Stem Cells
Embryonic Stem Cells
Cell Transplantation
Liver Failure
Cell- and Tissue-Based Therapy
Phenotype
Therapeutics

Cite this

Transdifferentiation and metaplasia as a paradigm for understanding development and disease. / Eberhard, D; Tosh, D.

In: Cellular and Molecular Life Sciences (CMLS), Vol. 65, No. 1, 01.2008, p. 33-40.

Research output: Contribution to journalArticle

@article{91588d112c344a3aa93387e9afea3996,
title = "Transdifferentiation and metaplasia as a paradigm for understanding development and disease",
abstract = "The ability to produce differentiated cell types at will offers one approach to cell therapy and therefore the treatment and cure of degenerative diseases such as diabetes and liver failure. Until recently it was thought that differentiated cells could only be produced from embryonic or adult stem cells. However, we now know that this is not the case, and there is a growing body of evidence to show that one differentiated cell type can convert into a completely different phenotype (transdifferentiation). Understanding the cellular and molecular basis of transdifferentiation will allow us to reprogram cells for transplantation. This approach will complement the use of embryonic and adult stem cells in the treatment of degenerative disorders. In this review, we will focus on some well-documented examples of transdifferentiation.",
author = "D Eberhard and D Tosh",
note = "ID number: ISI:000252671100005",
year = "2008",
month = "1",
doi = "10.1007/s00018-007-7428-9",
language = "English",
volume = "65",
pages = "33--40",
journal = "Cellular and Molecular Life Sciences (CMLS)",
issn = "1420-682X",
publisher = "Birkhauser Verlag Basel",
number = "1",

}

TY - JOUR

T1 - Transdifferentiation and metaplasia as a paradigm for understanding development and disease

AU - Eberhard, D

AU - Tosh, D

N1 - ID number: ISI:000252671100005

PY - 2008/1

Y1 - 2008/1

N2 - The ability to produce differentiated cell types at will offers one approach to cell therapy and therefore the treatment and cure of degenerative diseases such as diabetes and liver failure. Until recently it was thought that differentiated cells could only be produced from embryonic or adult stem cells. However, we now know that this is not the case, and there is a growing body of evidence to show that one differentiated cell type can convert into a completely different phenotype (transdifferentiation). Understanding the cellular and molecular basis of transdifferentiation will allow us to reprogram cells for transplantation. This approach will complement the use of embryonic and adult stem cells in the treatment of degenerative disorders. In this review, we will focus on some well-documented examples of transdifferentiation.

AB - The ability to produce differentiated cell types at will offers one approach to cell therapy and therefore the treatment and cure of degenerative diseases such as diabetes and liver failure. Until recently it was thought that differentiated cells could only be produced from embryonic or adult stem cells. However, we now know that this is not the case, and there is a growing body of evidence to show that one differentiated cell type can convert into a completely different phenotype (transdifferentiation). Understanding the cellular and molecular basis of transdifferentiation will allow us to reprogram cells for transplantation. This approach will complement the use of embryonic and adult stem cells in the treatment of degenerative disorders. In this review, we will focus on some well-documented examples of transdifferentiation.

UR - http://www.scopus.com/inward/record.url?scp=38549087544&partnerID=8YFLogxK

UR - http://dx.doi.org/10.1007/s00018-007-7428-9

U2 - 10.1007/s00018-007-7428-9

DO - 10.1007/s00018-007-7428-9

M3 - Article

VL - 65

SP - 33

EP - 40

JO - Cellular and Molecular Life Sciences (CMLS)

JF - Cellular and Molecular Life Sciences (CMLS)

SN - 1420-682X

IS - 1

ER -