Transdermal microneedles for drug delivery applications

Ai Ling Teo; Christopher Shearwood; Kian Chye Ng; Jia Lu; Shabbir Moochhala

doi:10.1016/j.mseb.2006.02.008

Transdermal microneedles for drug delivery applications

Ai Ling Teo, Christopher Shearwood, Kian Chye Ng, Jia Lu, Shabbir Moochhala

Research output: Contribution to journal › Article › peer-review

100 Citations (SciVal)

Abstract

Transdermal drug delivery (TDD) has many advantages, the main one being the ability to maintain the prolonged release of drugs to attain optimal blood concentrations. Unfortunately, nature has provided a very effective protective barrier, the stratum corneum (sc), which limits TDD to certain types of drugs with specific properties. In order to enhance TDD, the idea of using microneedles to painlessly penetrate the sc barrier has previously been proposed. In this paper, we will review the different microneedles that are currently being developed as well as our own efforts in this area. Based on our experiences, we will offer our view on the key parameters for effective transdermal microneedle design as well as future directions in this area.

Original language	English
Pages (from-to)	151-154
Number of pages	4
Journal	Materials Science and Engineering: B
Volume	132
Issue number	1-2
DOIs	https://doi.org/10.1016/j.mseb.2006.02.008
Publication status	Published - 25 Jul 2006

Keywords

MEMS
Microneedles
Transdermal drug delivery

ASJC Scopus subject areas

General Materials Science
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

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10.1016/j.mseb.2006.02.008

Cite this

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title = "Transdermal microneedles for drug delivery applications",

abstract = "Transdermal drug delivery (TDD) has many advantages, the main one being the ability to maintain the prolonged release of drugs to attain optimal blood concentrations. Unfortunately, nature has provided a very effective protective barrier, the stratum corneum (sc), which limits TDD to certain types of drugs with specific properties. In order to enhance TDD, the idea of using microneedles to painlessly penetrate the sc barrier has previously been proposed. In this paper, we will review the different microneedles that are currently being developed as well as our own efforts in this area. Based on our experiences, we will offer our view on the key parameters for effective transdermal microneedle design as well as future directions in this area.",

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AU - Teo, Ai Ling

AU - Shearwood, Christopher

AU - Ng, Kian Chye

AU - Lu, Jia

AU - Moochhala, Shabbir

PY - 2006/7/25

Y1 - 2006/7/25

N2 - Transdermal drug delivery (TDD) has many advantages, the main one being the ability to maintain the prolonged release of drugs to attain optimal blood concentrations. Unfortunately, nature has provided a very effective protective barrier, the stratum corneum (sc), which limits TDD to certain types of drugs with specific properties. In order to enhance TDD, the idea of using microneedles to painlessly penetrate the sc barrier has previously been proposed. In this paper, we will review the different microneedles that are currently being developed as well as our own efforts in this area. Based on our experiences, we will offer our view on the key parameters for effective transdermal microneedle design as well as future directions in this area.

AB - Transdermal drug delivery (TDD) has many advantages, the main one being the ability to maintain the prolonged release of drugs to attain optimal blood concentrations. Unfortunately, nature has provided a very effective protective barrier, the stratum corneum (sc), which limits TDD to certain types of drugs with specific properties. In order to enhance TDD, the idea of using microneedles to painlessly penetrate the sc barrier has previously been proposed. In this paper, we will review the different microneedles that are currently being developed as well as our own efforts in this area. Based on our experiences, we will offer our view on the key parameters for effective transdermal microneedle design as well as future directions in this area.

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ER -

Transdermal microneedles for drug delivery applications

Abstract

Keywords

ASJC Scopus subject areas

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