TY - JOUR
T1 - Transdermal drug delivery
T2 - Overcoming the skin's barrier function
AU - Naik, Aarti
AU - Kalia, Yogeshvar N.
AU - Guy, Richard H.
PY - 2000/9/1
Y1 - 2000/9/1
N2 - The skin represents an extraordinary evolutionary feat. Not only does it physically encapsulate the organism and provide a multifunctional interface between us and our surroundings, but it is perpetually engaged in the assembly of a highly efficient homeostatic barrier to the outward loss of water. In so doing, it furnishes a membrane that is equally adept at limiting molecular transport both from and into the body. Overcoming this barrier function then, for the purpose of transdermal drug delivery, has been a necessarily challenging task for the pharmaceutical scientist, and one that boasts significant progress.
AB - The skin represents an extraordinary evolutionary feat. Not only does it physically encapsulate the organism and provide a multifunctional interface between us and our surroundings, but it is perpetually engaged in the assembly of a highly efficient homeostatic barrier to the outward loss of water. In so doing, it furnishes a membrane that is equally adept at limiting molecular transport both from and into the body. Overcoming this barrier function then, for the purpose of transdermal drug delivery, has been a necessarily challenging task for the pharmaceutical scientist, and one that boasts significant progress.
UR - http://www.scopus.com/inward/record.url?scp=0034282141&partnerID=8YFLogxK
U2 - 10.1016/S1461-5347(00)00295-9
DO - 10.1016/S1461-5347(00)00295-9
M3 - Review article
AN - SCOPUS:0034282141
VL - 3
SP - 318
EP - 326
JO - Pharmaceutical Science and Technology Today
JF - Pharmaceutical Science and Technology Today
SN - 1461-5347
IS - 9
ER -