A pharmacokinetic model to describe transdermal drug delivery has been developed. The rate constants in this approach have been assigned on the basis of the physicochemical parameters of the penetrant. The equations produced will allow the estimation of the plasma levels of the drug following the dermal application of a rate-controlling device. This simplified approach will not allow for rate control by the stratum corneum. The model has been used to calculate the theoretical levels of clonidine after it has been applied in a transdermal system.

Original languageEnglish
Pages (from-to)267-274
Number of pages8
JournalInternational Journal of Pharmaceutics
Issue number2-3
Publication statusPublished - 31 May 1985


  • clonidine
  • percutaneous absorption
  • pharmacokinetics
  • transdermal drug delivery

ASJC Scopus subject areas

  • Pharmaceutical Science


Dive into the research topics of 'Transdermal drug delivery: a simplified pharmacokinetic approach'. Together they form a unique fingerprint.

Cite this