The current status of transdermal drug delivery is reviewed. The advantages and drawbacks of systemic drug input via the skin are detailed. Specific examples of transdermally delivered drugs are considered and the delivery systems employed are described. A kinetic analysis of transdermal drug delivery and percutaneous absorption is presented and its application to the prediction of plasma drug concentration versus time profiles following topical administration is demonstrated. Finally, the outstanding unknowns and areas requiring further research are identified and the prognosis for the future utility of this mode of drug administration is addressed.

Original languageEnglish
Pages (from-to)237-251
Number of pages15
JournalJournal of Controlled Release
Issue number4
Publication statusPublished - 28 Feb 1987

Bibliographical note

Funding Information:
Financial support was provided by N.I.H. grants GM-3339502 and AG-04851. RHG is the recipient of a Special Emphasis Research Career Award (l-KOl-OH00017-02) from the National Institute of Occupational Safety and Health, Centers for Disease Control. We thank Andrea Maze1 for careful manuscript preparation.

ASJC Scopus subject areas

  • Pharmaceutical Science


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