Transcriptional regulation and biological significance of the insulin like growth factor II gene

W. Engström; A Shokrai; K Otte; M Granérus; A Gessbo; P Bierke; A Madej; M Sjölund; A Ward

doi:10.1111/j.1365-2184.1998.tb01196.x

Transcriptional regulation and biological significance of the insulin like growth factor II gene

W. Engström, A Shokrai, K Otte, M Granérus, A Gessbo, P Bierke, A Madej, M Sjölund, A Ward

Department of Life Sciences

Swedish University of Agricultural Sciences

Research output: Contribution to journal › Review article › peer-review

46 Citations (SciVal)

Abstract

The insulin like growth factors I and II are the most ubiquitous in the mammalian embryo. Moreover they play a pivotal role in the development and growth of tumours. The bioavailability of these growth factors is regulated on a transcriptional as well as on a posttranslational level. The expression of non-signalling receptors as well as binding proteins does further tune the local concentration of IGFs. This paper aims at reviewing how the transcription of the IGF genes is regulated. The biological significance of these control mechanisms will be discussed.

Original language	English
Pages (from-to)	173-189
Number of pages	17
Journal	Cell Proliferation
Volume	31
Issue number	5-6
DOIs	https://doi.org/10.1111/j.1365-2184.1998.tb01196.x
Publication status	Published - Oct 1998

Keywords

Animals
Gene Expression Regulation, Developmental
Genomic Imprinting
Humans
Insulin-Like Growth Factor II
Transcription, Genetic
Journal Article
Research Support, Non-U.S. Gov't
Review

Access to Document

10.1111/j.1365-2184.1998.tb01196.x

Cite this

@article{6dba8d61ff7c480f9e0a7ca93f7e8444,

title = "Transcriptional regulation and biological significance of the insulin like growth factor II gene",

abstract = "The insulin like growth factors I and II are the most ubiquitous in the mammalian embryo. Moreover they play a pivotal role in the development and growth of tumours. The bioavailability of these growth factors is regulated on a transcriptional as well as on a posttranslational level. The expression of non-signalling receptors as well as binding proteins does further tune the local concentration of IGFs. This paper aims at reviewing how the transcription of the IGF genes is regulated. The biological significance of these control mechanisms will be discussed.",

keywords = "Animals, Gene Expression Regulation, Developmental, Genomic Imprinting, Humans, Insulin-Like Growth Factor II, Transcription, Genetic, Journal Article, Research Support, Non-U.S. Gov't, Review",

author = "W. Engstr{\"o}m and A Shokrai and K Otte and M Gran{\'e}rus and A Gessbo and P Bierke and A Madej and M Sj{\"o}lund and A Ward",

year = "1998",

month = oct,

doi = "10.1111/j.1365-2184.1998.tb01196.x",

language = "English",

volume = "31",

pages = "173--189",

journal = "Cell Proliferation",

issn = "0960-7722",

publisher = "Wiley-Blackwell",

number = "5-6",

}

TY - JOUR

T1 - Transcriptional regulation and biological significance of the insulin like growth factor II gene

AU - Engström, W.

AU - Shokrai, A

AU - Otte, K

AU - Granérus, M

AU - Gessbo, A

AU - Bierke, P

AU - Madej, A

AU - Sjölund, M

AU - Ward, A

PY - 1998/10

Y1 - 1998/10

N2 - The insulin like growth factors I and II are the most ubiquitous in the mammalian embryo. Moreover they play a pivotal role in the development and growth of tumours. The bioavailability of these growth factors is regulated on a transcriptional as well as on a posttranslational level. The expression of non-signalling receptors as well as binding proteins does further tune the local concentration of IGFs. This paper aims at reviewing how the transcription of the IGF genes is regulated. The biological significance of these control mechanisms will be discussed.

AB - The insulin like growth factors I and II are the most ubiquitous in the mammalian embryo. Moreover they play a pivotal role in the development and growth of tumours. The bioavailability of these growth factors is regulated on a transcriptional as well as on a posttranslational level. The expression of non-signalling receptors as well as binding proteins does further tune the local concentration of IGFs. This paper aims at reviewing how the transcription of the IGF genes is regulated. The biological significance of these control mechanisms will be discussed.

KW - Animals

KW - Gene Expression Regulation, Developmental

KW - Genomic Imprinting

KW - Humans

KW - Insulin-Like Growth Factor II

KW - Transcription, Genetic

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1111/j.1365-2184.1998.tb01196.x

DO - 10.1111/j.1365-2184.1998.tb01196.x

M3 - Review article

C2 - 9925986

SN - 0960-7722

VL - 31

SP - 173

EP - 189

JO - Cell Proliferation

JF - Cell Proliferation

IS - 5-6

ER -

Transcriptional regulation and biological significance of the insulin like growth factor II gene

Abstract

Keywords

Access to Document

Fingerprint

Cite this