Transcellular uptake mechanisms of the intestinal epithelial barrier - Part one

Ann L. Daugherty, Randall J. Mrsny

Research output: Contribution to journalReview articlepeer-review

138 Citations (SciVal)


Part one of this two-part review addresses the transport of therapeutics across the intestinal barrier, and focuses on transcellular transport through the intestinal epithelia. The anatomical, biochemical and physiological parameters impacting transcellular uptake of orally administered drugs are described, and methods for overcoming obstacles limiting successful transcellular oral drug delivery are discussed. Part two will cover paracellular transport.

Original languageEnglish
Pages (from-to)144-151
Number of pages8
JournalPharmaceutical Science and Technology Today
Issue number4
Publication statusPublished - 1 Apr 1999

ASJC Scopus subject areas

  • Pharmaceutical Science


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